You have no items in your shopping cart.
Search results for 'LY 215840'
-
I-CBP 112
I-CBP 112 is a CREBBP/EP300 bromodomain inhibitor (IC50 values are 0.142-0.17 and 0.625 μM for CREBBP and EP300 respectively). Learn MoreStarting at: $199.00
-
GPP 78 hydrochloride
GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Learn MoreStarting at: $169.00
-
Galloflavin
Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate), which inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells. Learn MoreStarting at: $109.00
-
UNC 1215
UNC 1215 is a potent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM), which displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Learn MoreStarting at: $149.00
-
SGC 0946
SGC 0946 is a potent DOT1L methyltransferase inhibitor (KD = 0.06 nM, IC50 = 0.3 nM in a radioactive assay) which blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8 nM respectively). Learn MoreStarting at: $199.00
-
TC-H 106
TC-H 106 is a class I histone deacetylase (HDAC) inhibitor with IC50 values of 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively. Learn MoreStarting at: $125.00
-
ZM 39923 hydrochloride
ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) with pIC50 values of 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Learn MoreStarting at: $119.00
-
TCS PIM-1 1
TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively). Learn MoreStarting at: $109.00
-
BVT 948
BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Learn MoreStarting at: $95.00
-
INCA-6
INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Learn MoreStarting at: $95.00
-
TCS 401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively). Learn MoreStarting at: $139.00
-
1,2,3,4,5,6-Hexabromocyclohexane
1,2,3,4,5,6-Hexabromocyclohexane potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. Learn MoreStarting at: $75.00
-
TCS 21311
TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM), which inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively). Learn MoreStarting at: $155.00
-
UNC 0224
UNC 0224 is a potent inhibitor of G9a histone lysine methyltransferase (IC50 = 15 nM). Learn MoreStarting at: $135.00
-
UNC 926 hydrochloride
UNC 926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM), which selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay. Learn MoreStarting at: $110.00
-
ZM 449829
Potent is a selective inhibitor of Janus tyrosine kinase 3 (JAK3), which binds competitively to the JAK3 ATP site. And inhibits STAT-5 phosphorylation and T-cell proliferation. Learn MoreStarting at: $89.00
