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Search results for 'as'
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R 59022
R 59022 is a diacylglycerol (DAG) kinase inhibitor with an IC50 value of 2.8 μM. Learn MoreStarting at: $105.00
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Acipimox
Acipimox is an antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels. Learn MoreStarting at: $65.00
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Tramiprosate
Tramiprosate is a sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form, which decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Learn MoreStarting at: $49.00
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8-Chloroadenosine
8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP, which incorporates into RNA during transcription and inhibits RNA synthesis and exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. Learn MoreStarting at: $145.00
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TCS PrP Inhibitor 13
TCS PrP Inhibitor 13 is an antiprion agent, which potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Learn MoreStarting at: $105.00
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SMER 28
SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway, which increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's disease and Parkinson's disease, respectively. Learn MoreStarting at: $85.00
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Homoharringtonine
Homoharringtonine is an inhibitor of protein synthesis which blocks elongation phase of translation by binding to the 60-S ribosome subunit. Learn MoreStarting at: $119.00
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Trovafloxacin mesylate
Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Learn MoreStarting at: $135.00
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B2
B2 Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease, which prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. Learn MoreStarting at: $90.00
