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Transporters

Amitriptyline hydrochloride

Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenalin uptake and also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Learn More

Starting at: $32.00

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Sertraline hydrochloride

Sertraline hydrochloride is a potent, orally active selective serotonin re-uptake inhibitor (SSRI). Learn More

Starting at: $109.00

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Indatraline hydrochloride

Indatraline hydrochloride is a potent monoamine uptake inhibitor that inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET). Learn More

Starting at: $95.00

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(±)-MDMA hydrochloride

(±)-MDMA hydrochloride is a hallucinogenic compound that inhibits 5-HT and dopamine uptake. Learn More

Starting at: $105.00

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(±)-McN 5652

(±)-McN 5652 is a potent, high affinity serotonin re-uptake inhibitor; selective in viv, and displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Learn More

Starting at: $139.00

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(S)-Duloxetine hydrochloride

(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HTand NA reuptake respectively in cortical synaptosomes, which exhibits antidepressant and anxiolytic effects. Learn More

Starting at: $45.00

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Reversan

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Learn More

Starting at: $139.00

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Fumitremorgin C

Fumitremorgin is a chemosensitizing agent which selectively reverses BCRP-mediated multidrug resistance. Learn More

Starting at: $170.00

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Elacridar hydrochloride

P-glycoprotein (P-gp/ABCG1) inhibitor, which blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. It also inhibits breast cancer resistance protein (BCRP/ABCG2). Learn More

Starting at: $100.00

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CP 100356 hydrochloride

CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms) which inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Learn More

Starting at: $155.00

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XR 9051 HCl

XR 9051 HCl is a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) that inhibits the binding of cytotoxics to P-glycoprotein (EC50 = 134 nM). Learn More

Starting at: $135.00

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(±)-Vesamicol hydrochloride

(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM), which centrally active following systemic administration in vivo. Learn More

Starting at: $69.00

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Concanamycin A

Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. Learn More

Starting at: $99.00

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Desipramine hydrochloride

Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters with Ki values of 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively. Learn More

Starting at: $41.00

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Talopram hydrochloride

Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) with selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Learn More

Starting at: $139.00

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Talsupram hydrochloride

Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor which exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Learn More

Starting at: $129.00

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Bicifadine hydrochloride

Bicifadine hydrochloride is an orally active, potent antagonist of the noradrenalin transporter with antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Learn More

Starting at: $139.00

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UCM 707

UCM 707 is a potent endocannabinoid transport inhibitor. IC50 values are 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH respectively. Ki values are 4700, 67 and > 5000 nM for CB1, CB2 and VR1 receptors respectively. Learn More

Starting at: $125.00

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Benzamil

Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 . Learn More

Starting at: $50.00

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SN-6

SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor which displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Learn More

Starting at: $115.00

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