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Transporters
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Dilazep dihydrochloride
Dilazep dihydrochloride is a coronary and cerebral vasodilator, suppresses the effects of ischemia. Learn MoreStarting at: $90.00
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N2-Methyl-L-arginine
N2-Methyl-L-arginine is a selective L-arginine uptake inhibitor (Ki = 500 μM) which inhibits uptake of arginine by the lysosomal system c in human fibroblast in vitro. Learn MoreStarting at: $119.00
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VU 0240551
VU 0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 that also inhibits hERG and L-type Ca2+ channels. Learn MoreStarting at: $115.00
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Decynium 22
Decynium 22 is an inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM). Learn MoreStarting at: $49.00
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Org 24598 lithium salt
Org 24598 lithium salt is a selective inhibitor of the glial glycine transporter (GlyT1). pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively. Learn MoreStarting at: $139.00
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LY 2365109 hydrochloride
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor that induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Learn MoreStarting at: $149.00
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Org 25543 hydrochloride
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2), which displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Learn MoreStarting at: $139.00
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NFPS
NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity on GlyT2 or the transport of proline, GABA or glutamate (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Learn MoreStarting at: $139.00
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Sarcosine
Sarcosine is an endogenous inhibitor of GlyT1 that displays antipsychotic activity. Learn MoreStarting at: $55.00
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MPDC
MM 77 dihydrochloride is a highly potent and fairly selective 5-HT1A ligand, which may be a full antagonist at postsynaptic receptors. Learn MoreStarting at: $135.00
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Chicago Sky Blue 6B
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM) and MIF proinflammatory activity. Learn MoreStarting at: $49.00
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DL-TBOA
DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 70, 6, and 6 μM for EAAT1, EAAT2 and EAAT3 respectively), which also inhibits EAAT4 and EAAT5 (Ki values are 4.4 and 3.2 μM respectively). Learn MoreStarting at: $140.00
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TFB-TBOA
TFB-TBOA is a high affinity, selective blocker of glial glutamate transporters EAAT1 and EAAT2 (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively), which displays no activity on a wide range of neurotransmitter receptors and transporters. Learn MoreStarting at: $89.00
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(±)-HIP-A
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Learn MoreStarting at: $139.00
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(±)-HIP-B
(±)-HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Learn MoreStarting at: $139.00
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Dihydrokainic acid
Dihydrokainic acid is a EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake. Learn MoreStarting at: $49.00
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Lithium carbonate
Lithium carbonate is thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Learn MoreStarting at: $29.00
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Evans Blue tetrasodium salt
Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). Learn MoreStarting at: $65.00
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L-CCG-lll
L-CCG-lll is a potent and competitive inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate. Learn MoreStarting at: $265.00
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Ceftriaxone disodium salt
Ceftriaxone disodium salt is β-lactam antibiotic, which increased activity of the EAAT2 glutamate transporter and displays neuroprotective activity in vivo via upregulation. Learn MoreStarting at: $49.00
