Transient Receptor Potential Channels

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  • Phenamil

    Phenamil is TRPP3 channel inhibitor (IC50 = 0.14 μM), which also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Learn More

    Starting at: $55.00

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  • EIPA

    EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM), which inhibits the Na+/H+ exchanger (NHE). Learn More

    Starting at: $65.00

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  • ML SA1

    ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Learn More

    Starting at: $75.00

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  • AMTB hydrochloride

    AMTB hydrochloride is a TRPM8 channel blocker that inhibits icilin- induced TRPM8 channel activation in a rat model. Learn More

    Starting at: $139.00

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  • WS 12

    WS 12 is a potent TRPM8 agonist that acts as a cooling agent with EC50 value of 193 nM. Learn More

    Starting at: $99.00

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  • 9-Phenanthrol

    9-Phenanthrol is a selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells), which exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Learn More

    Starting at: $49.00

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  • WS 3

    WS 3 is a cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM). Learn More

    Starting at: $69.00

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  • Pyr3

    Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3), which Inhibits hypertrophic responses in cardiomyocyte and TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM). Learn More

    Starting at: $100.00

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  • SKF 96365 hydrochloride

    SKF 96365 hydrochloride is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1.It also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels. Learn More

    Starting at: $115.00

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  • ML 204

    ML 204 is a blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Learn More

    Starting at: $100.00

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  • Polygodial

    Polygodial is a TRPA1 channel activator that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Learn More

    Starting at: $119.00

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  • AP 18

    AP 18 is a Reversible TRPA1 channel blocker with IC50 values of 3.1 and 4.5 μM at human and mouse TRPA1 respectively. Learn More

    Starting at: $90.00

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  • RN 1734

    RN 1734 is a selective TRPV4 antagonist with IC50 values of 2.3, 5.9 and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4 receptors respectively. Learn More

    Starting at: $95.00

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  • HC 067047

    HC 067047 is a potent and selective TRPV4 antagonist that reversibly inhibits currents through mouse, human and rat TRPV4 orthologs. Learn More

    Starting at: $139.00

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  • 6-Iodonordihydrocapsaicin

    6-Iodonordihydrocapsaicin is a potent competitive vanilloid TRPV1 (VR1) receptor antagonist that inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro. Learn More

    Starting at: $115.00

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  • A 784168

    A 784168 is a potent TRPV1 antagonist with an IC50 value of 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin. Learn More

    Starting at: $139.00

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  • OLDA

    OLDA is a potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Learn More

    Starting at: $75.00

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  • PALDA

    PALDA is an endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Learn More

    Starting at: $75.00

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  • PPAHV

    PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM) that displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Learn More

    Starting at: $98.00

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  • 6'-Iodoresiniferatoxin

    6'-Iodoresiniferatoxin is a high affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1), which displays partial agonism at human VR1 and full agonism at rat VR1. Learn More

    Starting at: $159.00

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