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Ion Channels
Transient Receptor Potential Channels

Transient Receptor Potential Channels

SKF 96365 hydrochloride

SKF 96365 hydrochloride is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1.It also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels. Learn More

Starting at: $115.00

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Pyr3

Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3), which Inhibits hypertrophic responses in cardiomyocyte and TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM). Learn More

Starting at: $100.00

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WS 3

WS 3 is a cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM). Learn More

Starting at: $69.00

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9-Phenanthrol

9-Phenanthrol is a selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells), which exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Learn More

Starting at: $49.00

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WS 12

WS 12 is a potent TRPM8 agonist that acts as a cooling agent with EC50 value of 193 nM. Learn More

Starting at: $99.00

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AMTB hydrochloride

AMTB hydrochloride is a TRPM8 channel blocker that inhibits icilin- induced TRPM8 channel activation in a rat model. Learn More

Starting at: $139.00

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ML SA1

ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Learn More

Starting at: $75.00

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EIPA

EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM), which inhibits the Na+/H+ exchanger (NHE). Learn More

Starting at: $65.00

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Phenamil

Phenamil is TRPP3 channel inhibitor (IC50 = 0.14 μM), which also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Learn More

Starting at: $55.00

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