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KT 5823
KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively), which inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
Additional Info
Additional Info
| Catalog No. | ES1485 |
|---|---|
| CAS Number | 126643-37-6 |
| Formula | C29H25N3O5 |
| M. Wt | 495.53 |
| Purity | >98 % |
| Solubility | Soluble to 50 mM in DMSO |
| Chemical Name | (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester |
| Synonyms | N/A |
| Storage | Desiccate at -20°C |
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