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Potassium Channels
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NS 5806
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito), which increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM), and inhibits KV1.4-mediated currents independently of KChIP2. Learn MoreStarting at: $149.00
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NS 11021
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Learn MoreStarting at: $139.00
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UCL 2077
UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. Learn MoreStarting at: $105.00
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CyPPA
CyPPA is an activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels. Learn MoreStarting at: $115.00
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SKA 31
SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Learn MoreStarting at: $85.00
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NS 6180
NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively), which exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Learn MoreStarting at: $99.00
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BMS 191011
BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Learn MoreStarting at: $120.00
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UCL 1684
UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons) which blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively. Learn MoreStarting at: $119.00
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NS 1619
NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator which induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM). Learn MoreStarting at: $145.00
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Penitrem A
Penitrem A is a potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing α subunits only, and those containing α and β1 respectively), which blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo. Learn MoreStarting at: $75.00
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1-EBIO
1-EBIO is an activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. And it also induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Learn MoreStarting at: $65.00
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PNU 37883 hydrochloride
PNU 37883 hydrochloride acts as a novel antagonist selective for the vascular form of Kir6 (KATP) channel. It inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Learn MoreStarting at: $125.00
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P1075
P1075 is a potent Kir6 (KATP) channel opener that binds to SUR2A and SUR2B with high affinity with Kd values of 17 and 3 nM respectively. Learn MoreStarting at: $139.00
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Cromakalim
Cromakalim is a prototypical Kir6 (KATP) channel opener that relaxes rabbit isolated portal vein with an IC50 value of 21 nM . Learn MoreStarting at: $139.00
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Levcromakalim
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim. Learn MoreStarting at: $169.00
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VU 590 dihydrochloride
VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM), which also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Learn MoreStarting at: $85.00
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ZM 226600
ZM 226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties. Learn MoreStarting at: $95.00
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VU 591 hydrochloride
VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Learn MoreStarting at: $100.00
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Y-26763
Y-26763 is a kir6 (KATP) channel opener and active metabolite of Y-27152, which relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Learn MoreStarting at: $130.00
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Y-27152
Y-27152 is a prodrug of the Kir6 (KATP) channel opener Y-26763, which produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals. Learn MoreStarting at: $130.00
