Potassium Channels

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  • DMP 543

    Indirubin-3'-oxime is aprotein kinase inhibitor and inhibits cyclin-dependent kinases (IC50 = 0.18 - 3.33 μM) and GSK-3β (IC50 = 0.19 μM). Learn More

    Starting at: $95.00

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  • YS-035 hydrochloride

    YS-035 hydrochloride is a Ca2+ blocker that strikingly prolongs cardiac action potentials by inhibiting pacemaker current and K+ outward currents. Learn More

    Starting at: $79.00

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  • BL 1249

    BL 1249 is a putative potassium channel activator which exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively). Learn More

    Starting at: $115.00

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  • Cesium chloride

    Cesium chloride is a potassium channel blocker that prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β. Learn More

    Starting at: $39.00

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  • VU 591 hydrochloride

    VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Learn More

    Starting at: $100.00

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  • ML 133 hydrochloride

    ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Learn More

    Starting at: $85.00

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  • Y-27152

    Y-27152 is a prodrug of the Kir6 (KATP) channel opener Y-26763, which produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals. Learn More

    Starting at: $130.00

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  • Y-26763

    Y-26763 is a kir6 (KATP) channel opener and active metabolite of Y-27152, which relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Learn More

    Starting at: $130.00

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  • ZM 226600

    ZM 226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties. Learn More

    Starting at: $95.00

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  • VU 590 dihydrochloride

    VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM), which also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Learn More

    Starting at: $85.00

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  • PNU 37883 hydrochloride

    PNU 37883 hydrochloride acts as a novel antagonist selective for the vascular form of Kir6 (KATP) channel. It inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Learn More

    Starting at: $125.00

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  • P1075

    P1075 is a potent Kir6 (KATP) channel opener that binds to SUR2A and SUR2B with high affinity with Kd values of 17 and 3 nM respectively. Learn More

    Starting at: $139.00

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  • Cromakalim

    Cromakalim is a prototypical Kir6 (KATP) channel opener that relaxes rabbit isolated portal vein with an IC50 value of 21 nM . Learn More

    Starting at: $139.00

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  • Levcromakalim

    Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim. Learn More

    Starting at: $169.00

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  • NS 1619

    NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator which induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM). Learn More

    Starting at: $145.00

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  • UCL 1684

    UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons) which blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively. Learn More

    Starting at: $119.00

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  • BMS 191011

    BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Learn More

    Starting at: $120.00

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  • NS 6180

    NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively), which exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Learn More

    Starting at: $99.00

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  • CyPPA

    CyPPA is an activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels. Learn More

    Starting at: $115.00

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  • UCL 2077

    UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. Learn More

    Starting at: $105.00

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