You have no items in your shopping cart.
Nuclear Receptors
-
BMS 753
BMS 753 is a RARα-selective agonist (Ki = 2 nM). Learn MoreStarting at: $120.00
-
BMS 195614
BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM) which displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Learn MoreStarting at: $159.00
-
AC 261066
AC 261066 is a potent RARβ2 agonist with a pEC50 value of 8.1. Learn MoreStarting at: $139.00
-
ER 50891
ER 50891 is a antagonist of RARα receptors (IC50 = 31.2 nM), which displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively). Learn MoreStarting at: $155.00
-
MM 11253
MM 11253 is a selective RARγ antagonist, which blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Learn MoreStarting at: $139.00
-
SR 11237
SR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity. Learn MoreStarting at: $135.00
-
UVI 3003
UVI 3003 is a RXR antagonist that displays high RXR binding affinity. Learn MoreStarting at: $115.00
-
Docosahexaenoic acid
Docosahexaenoic acid is a endogenous omega-3 fatty acid. It acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Learn MoreStarting at: $75.00
-
Fluorobexarotene
Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors), which displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene. Learn MoreStarting at: $160.00
-
LG 100754
LG 100754 is a novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity which displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Learn MoreStarting at: $140.00
-
HX 630
HX 630 is a RXR agonist, which acts as a retinoid synergist and enhances the potency of AM 80 in a HL-60 cell differentiation assay. Learn MoreStarting at: $149.00
-
CD 3254
CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. Learn MoreStarting at: $135.00
-
HX 531
HX 531 is a potent RXR antagonist (IC50 = 18 nM). Learn MoreStarting at: $149.00
-
LG 101506
LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively), which displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Learn MoreStarting at: $139.00
-
GC 1
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively), which displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Learn MoreStarting at: $115.00
-
Guggulsterone
Guggulsterone is a broad spectrum steroid receptor ligand that binds with high affinity to mineralocorticoid receptors and lower affinity to progesterone, androgen and glucocorticoid receptors. Learn MoreStarting at: $109.00
-
GSK 4112
GSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM) which enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Learn MoreStarting at: $100.00
-
SR 8278
SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM) and blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. Learn MoreStarting at: $115.00
-
SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
-
AC 45594
AC 45594 is a selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM), which inhibits SFRE-mediated transcription. Learn MoreStarting at: $70.00
