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Nuclear Receptors
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Clofibric acid
Clofibric acid is a PPAR agonist. Learn MoreStarting at: $55.00
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Corticosterone
Corticosterone is an endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors. Learn MoreStarting at: $85.00
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GSK 9027
GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8), which inhibits production of the proinflammatory mediator IL-6 in vivo. Learn MoreStarting at: $135.00
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GW 3965 hydrochloride
GW 3965 hydrochloride is a selective, orally active non-steroidal agonist for the liver X receptor (LXR). Learn MoreStarting at: $85.00
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Fexaramine
Fexaramine is a potent, selective farnesoid X receptor agonist with EC50 = 25 nM. Learn MoreStarting at: $155.00
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Spironolactone
Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo, displays antiandrogen activity and inhibits steroid hormone biosynthesis. Learn MoreStarting at: $45.00
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RU 26752
RU 26752 is a mineralocorticoid receptor antagonist that prevents aldosterone-induced hypertension in rats. Learn MoreStarting at: $89.00
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RU 28318 (potassium salt)
RU 28318 (potassium salt) is a potent and selective antagonist for the mineralocorticoid receptor (MR) that inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Learn MoreStarting at: $139.00
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Canrenone
Canrenone is a mineralocorticoid receptor antagonist. Learn MoreStarting at: $59.00
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SR 12813
SR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively), which activates the farnesoid X receptor (FXR) at μM concentrations. Learn MoreStarting at: $75.00
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Meclizine dihydrochloride
Meclizine dihydrochloride is a Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Learn MoreStarting at: $55.00
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AC 261066
AC 261066 is a potent RARβ2 agonist with a pEC50 value of 8.1. Learn MoreStarting at: $139.00
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AC 55649
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. Learn MoreStarting at: $99.00
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CD 2665
SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively) which displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. Learn MoreStarting at: $140.00
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BMS 453
R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist which displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM) and inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. Learn MoreStarting at: $135.00
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MM 11253
MM 11253 is a selective RARγ antagonist, which blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Learn MoreStarting at: $139.00
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BMS 195614
BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM) which displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Learn MoreStarting at: $159.00
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BMS 753
BMS 753 is a RARα-selective agonist (Ki = 2 nM). Learn MoreStarting at: $120.00
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BMS 493
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist, which enhances nuclear corepressor (NCoR) interaction with RARs. Learn MoreStarting at: $135.00
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EC 23
EC 23 is Photostable synthetic retinoid and displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Learn MoreStarting at: $135.00
