Nuclear Receptors
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S26948
S26948 is a selective PPARγ agonist (EC50 = 8.83 nM), which drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice, and displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats. Learn MoreStarting at: $139.00
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ERB 041
IC50 values of ERB 041 are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively. Learn MoreStarting at: $139.00
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PPT
PPT is a potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM) which displays 410-fold selectivity for ERα over ER&beta, and prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. Learn MoreStarting at: $119.00
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Cyclofenil
Cyclofenil is a non-steroidal selective estrogen receptor modulator (SERM) which displays higher affinity for estrogen receptor β (ERβ) than for ERα. Learn MoreStarting at: $65.00
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MPP dihydrochloride
MPP dihydrochloride is a selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ receptors respectively. Learn MoreStarting at: $109.00
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Estropipate
Estropipate is an estrogen receptor agonist that inhibits organic anion transporting polypeptide 1B1 (OATP1B1). Learn MoreStarting at: $75.00
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(R)-DPN
(R)-DPN, a enantiomer of DPN, displays higher affinity for estrogen receptor (ER) β over ERα with Ki values of 1.82 and 147 nM respectively . Learn MoreStarting at: $186.00
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WAY 200070
WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Learn MoreStarting at: $109.00
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α-Estradiol
α-Estradiol is a endogenous estrogen receptor ligand. Learn MoreStarting at: $49.00
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DPN
DPN is a highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα (EC50 values are 0.85 and 66 nM respectively), which shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus. Learn MoreStarting at: $90.00
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(R,R)-THC
(R,R)-THC is a non-steroidal, selective estrogen receptor ligand; agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM). Learn MoreStarting at: $225.00
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GSK 4716
GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERR&gamma, which displays selectivity over ERRα and the classical estrogen receptors. Learn MoreStarting at: $63.00
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Y 134
Y 134 is a selective estrogen receptor modulator (SERM) that acts as an agonist in the bone and antagonist in reproductive tissue. Learn MoreStarting at: $139.00
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RU 58668
RU 58668 is a pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM), which displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo. Learn MoreStarting at: $185.00
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FERb 033
FERb 033 is a Potent and selective ERβ receptor agonist (Ki = 7.1 nM, EC50 = 4.8 nM), which also displays 62-fold selectivity over ERα. Learn MoreStarting at: $105.00
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ZK 164015
ZK 164015 is a potent estrogen receptor silent antagonist which inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM). Learn MoreStarting at: $115.00
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PHTPP
PHTPP is a selective estrogen ERβ receptor antagonist that exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα. Learn MoreStarting at: $145.00
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DY131
DY131 is a novel selective agonist at estrogen-related receptors ERRβ and ERRγ that displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. Learn MoreStarting at: $95.00
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(Z)-4-Hydroxytamoxifen
(Z)-4-Hydroxytamoxifen is an estrogen receptor antagonist. Learn MoreStarting at: $139.00
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Clofibric acid
Clofibric acid is a PPAR agonist. Learn MoreStarting at: $55.00