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5-Iodo-A-85380 dihydrochloride
5-Iodo-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors, which activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively.
Additional Info
Additional Info
| Catalog No. | ES2286 |
|---|---|
| CAS Number | 213764-92-2 |
| Formula | C9H11IN2O.2HCl |
| M. Wt | 363.03 |
| Purity | >98 % |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| Chemical Name | 3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride |
| Synonyms | N/A |
| Storage | Desiccate at +4°C |
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