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Neurotransmitter Transporters
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Escitalopram oxalate
Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI) (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Learn MoreStarting at: $55.00
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(S)-Duloxetine hydrochloride
(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HTand NA reuptake respectively in cortical synaptosomes, which exhibits antidepressant and anxiolytic effects. Learn MoreStarting at: $45.00
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(±)-Vesamicol hydrochloride
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM), which centrally active following systemic administration in vivo. Learn MoreStarting at: $69.00
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Talsupram hydrochloride
Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor which exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Learn MoreStarting at: $129.00
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Desipramine hydrochloride
Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters with Ki values of 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively. Learn MoreStarting at: $41.00
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Bicifadine hydrochloride
Bicifadine hydrochloride is an orally active, potent antagonist of the noradrenalin transporter with antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Learn MoreStarting at: $139.00
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Talopram hydrochloride
Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) with selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Learn MoreStarting at: $139.00
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(-)-5'-DMH-CBD
(-)-5'-DMH-CBD is an anandamide membrane transport inhibitor (IC50 = 14 μM) that is relatively metabolically stable, which displays some affinity for CB2 receptors but has only weak affinity for CB1 receptors and has no activity at VR1 receptors or FAAH. Learn MoreStarting at: $149.00
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OMDM-2
OMDM-2 is a metabolically stable inhibitor of anandamide cellular uptake that displays relatively low affinity for CB1 and CB2 receptors with Ki values of 5.1 and > 10 μM and for vanilloid VR1 receptors with EC50 value of 10 μM. Learn MoreStarting at: $65.00
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O-2093
O-2093 is an inhibitor of anandamide uptake (IC50 = 17.3 μM) with little or no activity at CB1, CB2, TRPV1 and FAAH. Learn MoreStarting at: $99.00
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UCM 707
UCM 707 is a potent endocannabinoid transport inhibitor. IC50 values are 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH respectively. Ki values are 4700, 67 and > 5000 nM for CB1, CB2 and VR1 receptors respectively. Learn MoreStarting at: $125.00
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VDM 11
VDM 11 is a potent and selective inhibitor of the anandamide membrane transporter (AMT) with IC50 values of 4-11 μM, which displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Learn MoreStarting at: $75.00
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AM 1172
AM 1172 metabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Learn MoreStarting at: $139.00
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AM 404
AM 404 is a competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available in water soluble emulsion . Learn MoreStarting at: $65.00
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GBR 13069 dihydrochloride
GBR 13069 dihydrochloride is a potent inhibitor of dopamine uptake with an IC50 value of 40 nM. Learn MoreStarting at: $89.00
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GBR 12783 dihydrochloride
GBR 12783 dihydrochloride is a potent and selective inhibitor of dopamine uptake with IC50 value of 1.8 nM for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes. Learn MoreStarting at: $99.00
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Cocaine hydrochloride
Cocaine hydrochloride, a competitive inhibitor of monoamine neurotransmitter transporters, inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Learn MoreStarting at: $79.00
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Nomifensine
Nomifensine is a potent inhibitor of noradrenalin and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain), which increases central dopamine levels in rats following systemic administration. Learn MoreStarting at: $79.00
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Bupropion hydrochloride
Bupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively), which also inhibits neuronal nicotinic acetylcholine receptors. Learn MoreStarting at: $99.00
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Threo-methylphenidate hydrochloride
Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Learn MoreStarting at: $85.00
