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Neurotransmitter Transporters
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Decynium 22
Decynium 22 is an inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM). Learn MoreStarting at: $49.00
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Dilazep dihydrochloride
Dilazep dihydrochloride is a coronary and cerebral vasodilator, suppresses the effects of ischemia. Learn MoreStarting at: $90.00
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Sarcosine
Sarcosine is an endogenous inhibitor of GlyT1 that displays antipsychotic activity. Learn MoreStarting at: $55.00
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NFPS
NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity on GlyT2 or the transport of proline, GABA or glutamate (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Learn MoreStarting at: $139.00
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Org 25543 hydrochloride
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2), which displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Learn MoreStarting at: $139.00
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Org 24598 lithium salt
Org 24598 lithium salt is a selective inhibitor of the glial glycine transporter (GlyT1). pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively. Learn MoreStarting at: $139.00
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LY 2365109 hydrochloride
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor that induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Learn MoreStarting at: $149.00
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(±)-HIP-A
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Learn MoreStarting at: $139.00
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DL-TBOA
DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 70, 6, and 6 μM for EAAT1, EAAT2 and EAAT3 respectively), which also inhibits EAAT4 and EAAT5 (Ki values are 4.4 and 3.2 μM respectively). Learn MoreStarting at: $140.00
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7-Chlorokynurenic acid
7-Chlorokynurenic acid is a NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Learn MoreStarting at: $60.00
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7-Chlorokynurenic acid sodium salt
7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid, an NMDA receptor antagonist acting at the glycine site. Learn MoreStarting at: $65.00
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L-CCG-lll
L-CCG-lll is a potent and competitive inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate. Learn MoreStarting at: $265.00
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Ceftriaxone disodium salt
Ceftriaxone disodium salt is β-lactam antibiotic, which increased activity of the EAAT2 glutamate transporter and displays neuroprotective activity in vivo via upregulation. Learn MoreStarting at: $49.00
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Chicago Sky Blue 6B
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM) and MIF proinflammatory activity. Learn MoreStarting at: $49.00
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(±)-HIP-B
(±)-HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Learn MoreStarting at: $139.00
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Evans Blue tetrasodium salt
Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). Learn MoreStarting at: $65.00
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TFB-TBOA
TFB-TBOA is a high affinity, selective blocker of glial glutamate transporters EAAT1 and EAAT2 (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively), which displays no activity on a wide range of neurotransmitter receptors and transporters. Learn MoreStarting at: $89.00
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WAY 213613
WAY 213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3. Learn MoreStarting at: $139.00
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cis-ACBD
cis-ACBD is a potent, competitive and selective inhibitor of glutamate uptake. Learn MoreStarting at: $99.00
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L-(-)-threo-3-Hydroxyaspartic acid
L-(-)-threo-3-Hydroxyaspartic acid is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Learn MoreStarting at: $149.00
