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Ligand-gated Ion Channels
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TCN 213
TCN 213 is a NMDA receptor antagonist, selective for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B. Learn MoreStarting at: $149.00
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TQS
TQS is a type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Learn MoreStarting at: $125.00
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Norketamine hydrochloride
Norketamine hydrochloride is a major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Learn MoreStarting at: $99.00
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cis-ACPD
cis-ACPD is a 1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo. Learn MoreStarting at: $125.00
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D-Aspartic acid
Endogenous NMDA receptor agonist with similar activity to the L-isomer (L-aspartic acid). Learn MoreStarting at: $80.00
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AR-R 17779 hydrochloride
AR-R 17779 hydrochloride is a selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). Learn MoreStarting at: $140.00
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Synthalin sulfate
Synthalin sulfate is an effective non-competitive NMDA receptor antagonist in vivo and in vitro. Learn MoreStarting at: $85.00
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Ifenprodil hemitartrate
Ifenprodil hemitartrate is a NMDA receptor antagonist, acting at the polyamine site. Learn MoreStarting at: $65.00
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Co 101244 hydrochloride
Co 101244 hydrochloride is a novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Learn MoreStarting at: $119.00
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Ro 04-5595 hydrochloride
Ro 04-5595 hydrochloride is a selective antagonist for NR2B-containing NMDA receptors (Ki = 31 nM). Learn MoreStarting at: $129.00
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Ro 8-4304 hydrochloride
Ro 8-4304 hydrochloride is a NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors, which exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine. Learn MoreStarting at: $109.00
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ACBC
ACBC is a NMDA receptor partial agonist, acting at the glycine site of NR1. Learn MoreStarting at: $80.00
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TCS 46b
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively), whih potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. Learn MoreStarting at: $109.00
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S 24795
S 24795 is a partial agonist of α7 nAChR, which improves mnemonic function in aged mice for the treatment of aging-related memory disturbances and displays more efficient memory-enhancing effects than memantine in Alzheimer's disease mouse models. Learn MoreStarting at: $90.00
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Arcaine sulfate
Arcaine sulfate is a NO synthase inhibitor, acting as a competitive inhibitor at the polyamine site. Learn MoreStarting at: $80.00
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L-701,252
L-701,252 is an antagonist at the glycine-NMDA site (IC50 = 420 nM). Learn MoreStarting at: $95.00
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Gavestinel
Gavestinel is a highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), which displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo. Learn MoreStarting at: $100.00
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(S)-(+)-Ketamine hydrochloride
(S)-(+)-Ketamine hydrochloride is a NMDA receptor antagonist, which displays neuroprotective efficacy in vitro. Learn MoreStarting at: $85.00
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Spermidine trihydrochloride
Spermidine trihydrochloride binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801. Learn MoreStarting at: $65.00
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DMAB-anabaseine dihydrochloride
DMAB-anabaseine dihydrochloride is a partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Learn MoreStarting at: $119.00
