Ligand-gated Ion Channels
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ATPA
ATPA is a selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Learn MoreStarting at: $140.00
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ACET
ACET is a potent and selective GluR5-containing kainate receptor antagonist that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Learn MoreStarting at: $275.00
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(S)-(-)-5-Iodowillardiine
(S)-(-)-5-Iodowillardiine demonstrates high affinity for the kainate receptor subtype hGluR5 (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6. Learn MoreStarting at: $135.00
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Domoic acid
Domoic acid is more potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies. Learn MoreStarting at: $110.00
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MR 16728 hydrochloride
This analog of cetiedil stimulates the release of acetylcholine from synaptosomes. Learn MoreStarting at: $105.00
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SM-21 maleate
SM-21 maleate is a potent and selective σ2 antagonist with central effects following systemic administration. Learn MoreStarting at: $95.00
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PG-9 maleate
PG-9 maleate is a potent analgesic and nootropic agent. Increases release of acetylcholine. Learn MoreStarting at: $90.00
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SYM 2081
SYM 2081 is a potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Learn MoreStarting at: $139.00
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Kainic acid
Kainic acid is a selective agonist at kainate receptors. Potent excitant and neurotoxin. Learn MoreStarting at: $65.00
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UBP 301
UBP 301 is a potent kainate receptor antagonist that displays ~ 30-fold selectivity over AMPA receptors. Learn MoreStarting at: $139.00
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NS 3763
NS 3763 is a selective non-competitive kainate receptor antagonist that displays selectivity for GLUK5 subunit-containing receptors with IC50 values of 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively. Learn MoreStarting at: $99.00
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UBP 296
UBP 296 is a selective GluR5-subunit containing kainate receptor antagonist that displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Learn MoreStarting at: $149.00
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UBP 302
UBP 302, an active enantiomer of UBP 296, is a selective and potent GLUK5 (GluR5)-subunit containing kainate receptor antagonist that displays ~ 260-fold selectivity over AMPA receptors and ~ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors. Learn MoreStarting at: $195.00
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UBP 310
UBP 310 is a GLUK5 kainate receptor antagonist that also blocks recombinant homomeric GLUK7 receptors and displays 12,700-fold selectivity for GLUK5 over GLUK6. Learn MoreStarting at: $109.00
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β-Alanine
β-Alanine is a non-specific endogenous agonist at the inhibitory glycine receptor. More selective than taurine, which slso distinguishes between GABA transporters (IC50 values are 19, 58, 110, 1320 and 5690 μM for rGAT-2, hGAT-3, rGAT-3, hBGT-3 and hGAT-1 respectively). Learn MoreStarting at: $49.00
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Hypotaurine
Endogenous inhibitory amino acid. Learn MoreStarting at: $75.00
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L-Alanine
L-Alanine is an Agonist at the inhibitory glycine receptor. Learn MoreStarting at: $33.00
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L-Serine
L-Serine is an endogenous agonist at the inhibitory glycine receptor. Learn MoreStarting at: $33.00
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Carbamoylcholine chloride
Carbamoylcholine chloride is a cholinergic receptor agonist that is resistant to the action of cholinesterases. Learn MoreStarting at: $59.00
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L-BMAA hydrochloride
PNU 22394 hydrochloride is a potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Learn MoreStarting at: $65.00