Kinases

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  • H-7 dihydrochloride

    H-7 dihydrochloride is a protein kinase inhibitor. Learn More

    Starting at: $95.00

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  • H-9 dihydrochloride

    H-9 dihydrochloride is a protein kinase inhibitor that inhibits PKA, PKG, CaMK II, PKC, casein kinase I and casein kinase II. Learn More

    Starting at: $89.00

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  • Ro 31-8220 mesylate

    Ro 31-8220 mesylate is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Learn More

    Starting at: $95.00

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  • INDY

    INDY is a dyrk1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for Dyrk1B and Dyrk1A respectively), which binds at the ATP-binding cleft of the enzyme. Learn More

    Starting at: $105.00

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  • KH CB19

    KH CB19 is a selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1) which suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions, and displays selectivity over a panel of 71 protein kinases. Learn More

    Starting at: $65.00

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  • PF 06465469

    PF 06465469 is a potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM)which exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Learn More

    Starting at: $180.00

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  • DCA

    DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK), which shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria, and induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Learn More

    Starting at: $55.00

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  • Harmine

    Harmine is a potent and selective inhibitor of Dyrk1A (IC50 values are 80, 800 and 900 nM for Dyrk1A, Dyrk3 and Dyrk2 respectively), which shown to inhibit direct phosphorylation of tau by Dyrk1A (IC50 = 700 nM). Learn More

    Starting at: $49.00

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  • TNP

    TNP is a Reversible inositol hexakisphosphate kinase (IP6K) inhibitor with IC50 = 0.47 μM for inhibition of InsP7 formation. Learn More

    Starting at: $139.00

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  • PIR 3.5

    PIR 3.5 is a non-competitive inhibitor of group I p21-activated kinase (Pak1). Learn More

    Starting at: $92.00

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  • ±-AMG 487

    ±-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively), which inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Learn More

    Starting at: $189.00

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  • (Z)-FeCP-oxindole

    (Z)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn More

    Starting at: $179.00

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  • ProINDY

    ProINDY is a Dyrk1A/B inhibitor that inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Learn More

    Starting at: $125.00

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  • TG 003

    TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases that suppresses serine/arginine-rich protein phosphorylation and affects the regulation of alternative splicing by phosphorylation of SR protein both in vivo and in vitro. Learn More

    Starting at: $139.00

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  • (5Z)-7-Oxozeaenol

    (5Z)-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Learn More

    Starting at: $109.00

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  • ER 27319 maleate

    ER 27319 maleate is a selective inhibitor of Syk kinase which inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events. Learn More

    Starting at: $98.00

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  • KB SRC 4

    KB SRC 4 is a potent and selective c-Src inhibitor (Ki = 44 nM) and significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells. Learn More

    Starting at: $175.00

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  • MNS

    MNS is a selective inhibitor of Src and Syk tyrosine kinases which displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Learn More

    Starting at: $65.00

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  • Src I1

    Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively) which inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Learn More

    Starting at: $120.00

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  • AZM 475271

    AZM 475271 is a src tyrosine kinase inhibitor, which reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Learn More

    Starting at: $179.00

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