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Ion Channels
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PD 173212
PD 173212 is a potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM), which displays selectivity over K+, Na+ and L-type Ca2+ channels and prevents tonic seizures in the audiogenic seizure model in vivo. Learn MoreStarting at: $190.00
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QX 314 bromide
QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Learn MoreStarting at: $85.00
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QX 222
QX 222 is a sodium channel blocker. Learn MoreStarting at: $50.00
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AM 92016 hydrochloride
AM 92016 hydrochloride is a specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity which exhibits proarrhythmic and prohypertensive activity in vivo. Learn MoreStarting at: $110.00
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Co 102862
Co 102862 is a broad spectrum, state-dependent blocker of voltage-gated sodium channels which displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Learn MoreStarting at: $95.00
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KC 12291 hydrochloride
KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker which inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Learn MoreStarting at: $135.00
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CP 339818 hydrochloride
CP 339818 hydrochloride is a potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM), which inhibits KV1.4 with an IC50 of ~ 300 nM. Learn MoreStarting at: $120.00
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Tetrodotoxin citrate
Tetrodotoxin citrate is a highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin. Learn MoreStarting at: $139.00
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Amiloride hydrochloride
Amiloride hydrochloride is Na+ channel blocker, which defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding sites. Learn MoreStarting at: $55.00
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Ralfinamide mesylate
Ralfinamide mesylate is a sodium channel blocker, which suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Learn MoreStarting at: $65.00
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DQP 1105
DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM respectively). Learn MoreStarting at: $119.00
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cis-ACPD
cis-ACPD is a 1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo. Learn MoreStarting at: $125.00
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PHA 543613 hydrochloride
PHA 543613 hydrochloride is a potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors, which positively influences sensory gating and memory in in vivo models of schizophrenia. Learn MoreStarting at: $149.00
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CIQ
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit, which increases channel opening efficiency and enhances NMDA receptor responses. Learn MoreStarting at: $119.00
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Homoquinolinic acid
Homoquinolinic acid is a potent NMDA receptor agonist; subtype-selective. Learn MoreStarting at: $129.00
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NS 1738
NS 1738 is a selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Learn MoreStarting at: $99.00
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PHA 568487
PHA 568487 is an orally active and brain penetrant agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively). Learn MoreStarting at: $99.00
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TCN 213
TCN 213 is a NMDA receptor antagonist, selective for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B. Learn MoreStarting at: $149.00
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(±)-1-(1,2-Diphenylethyl)piperidine maleate
(±)-1-(1,2-Diphenylethyl)piperidine maleate is a high affinity antagonist at the ion channel on the NMDA receptor. Learn MoreStarting at: $85.00
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TQS
TQS is a type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Learn MoreStarting at: $125.00
