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ML 228
ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.
Additional Info
Additional Info
| Catalog No. | ES1619 |
|---|---|
| CAS Number | 1357171-62-0 |
| Formula | C27H21N5 |
| M. Wt | 415.49 |
| Purity | >98 % |
| Solubility | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| Chemical Name | N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine |
| Synonyms | N/A |
| Storage | Store at -20°C |
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