Glutamate (Metabotropic) Receptors

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  • ACPT-II

    ACPT-II is a competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively). Learn More

    Starting at: $140.00

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  • L-Glutamic acid

    L-Glutamic is the predominant excitatory transmitter in the mammalian central nervous system. It acts at ionotropic and metabotropic glutamate receptors. Learn More

    Starting at: $32.00

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  • DCG IV

    DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors. Learn More

    Starting at: $135.00

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  • MAP4

    (S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Learn More

    Starting at: $135.00

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  • LY 487379 hydrochloride

    LY 487379 hydrochloride is a positive allosteric modulator selective for mGlu2 receptors, which potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 μM for mGlu2 and mGlu3 receptors respectively). Learn More

    Starting at: $110.00

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  • Spaglumic acid

    Spaglumic acid is the most abundant peptide neurotransmitter in the mammalian CNS. Learn More

    Starting at: $109.00

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  • Ro 64-5229

    Ro 64-5229 is a selective, non-competitive mGlu2 antagonist which inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM). Learn More

    Starting at: $140.00

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  • EGLU

    EGLU is a selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Learn More

    Starting at: $110.00

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  • L-CCG-l

    L-CCG-l is a potent group II metabotropic glutamate receptor agonist. Learn More

    Starting at: $185.00

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  • (2R,4R)-APDC

    MSPG is a selatively non-selective antagonist of presynaptic mGlu receptors in neonatal rat spinal cord and adult rat cerebrocortical mGlu receptors. Learn More

    Starting at: $165.00

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  • (E)-FeCP-oxindole

    (E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn More

    Starting at: $179.00

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  • MSPG

    MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices. Learn More

    Starting at: $135.00

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  • CHIR 99021 trihydrochloride

    CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021, a highly selective GSK-3 inhibitor. Learn More

    Starting at: $189.00

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  • NPEC-caged-LY 379268

    NPEC ((N)-1-(2-Nitrophenyl)ethoxycarbonyl) caged version of LY 379268, selective group II mGlu receptor agonist. Learn More

    Starting at: $345.00

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  • MNI 137

    MNI 137 is a selective negative allosteric modulator of group II mGlu receptors with IC50 values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. Learn More

    Starting at: $139.00

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  • CBiPES hydrochloride

    CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor with an IC50 value of 98.2 nM. Learn More

    Starting at: $115.00

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  • Xanthurenic acid

    Xanthurenic acid attenuates cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors. Learn More

    Starting at: $39.00

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  • (RS)-APICA

    PNU 96415E is antipsychotic agent which displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Learn More

    Starting at: $105.00

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  • MTPG

    RS 17053 hydrochloride is a α1A-adrenoceptor antagonist, with very high affinity for α1A receptors (pKi and pA2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α1B and α1D subtypes (pKi and pA2 estimates 7.7 - 7.8). Learn More

    Starting at: $135.00

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  • (S)-3,5-DHPG

    BYK 49187 is a PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively) which displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro. Learn More

    Starting at: $95.00

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