You have no items in your shopping cart.
Glutamate (Metabotropic) Receptors
-
Ro 67-4853
Ro 67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor) which exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Learn MoreStarting at: $90.00
-
Ro 01-6128
Ro 01-6128 is a positive allosteric modulator of mGlu1 receptors, which potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a). Learn MoreStarting at: $85.00
-
Desmethyl-YM 298198
Desmethyl-YM 298198 is a derivative of the mGlu1-selective antagonist YM 298198. Learn MoreStarting at: $139.00
-
YM 202074
High affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist which binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Learn MoreStarting at: $139.00
-
Ro 67-7476
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors which potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Learn MoreStarting at: $129.00
-
Bay 36-7620
Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity, which exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration. Learn MoreStarting at: $155.00
-
NPS 2390
NPS 2390is a group I mGlu antagonist which displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Learn MoreStarting at: $119.00
-
DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
-
LY 367385
LY 367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu5a, and negligible action on group II and III receptors. Learn MoreStarting at: $119.00
-
(RS)-APICA
PNU 96415E is antipsychotic agent which displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Learn MoreStarting at: $105.00
-
Xanthurenic acid
Xanthurenic acid attenuates cAMP formation in mouse cortical slices expressing mGlu2 and mGlu3 receptors. Learn MoreStarting at: $39.00
-
CBiPES hydrochloride
CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor with an IC50 value of 98.2 nM. Learn MoreStarting at: $115.00
-
MNI 137
MNI 137 is a selective negative allosteric modulator of group II mGlu receptors with IC50 values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. Learn MoreStarting at: $139.00
-
NPEC-caged-LY 379268
NPEC ((N)-1-(2-Nitrophenyl)ethoxycarbonyl) caged version of LY 379268, selective group II mGlu receptor agonist. Learn MoreStarting at: $345.00
-
(E)-FeCP-oxindole
(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
-
CHIR 99021 trihydrochloride
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021, a highly selective GSK-3 inhibitor. Learn MoreStarting at: $189.00
-
MTPG
RS 17053 hydrochloride is a α1A-adrenoceptor antagonist, with very high affinity for α1A receptors (pKi and pA2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α1B and α1D subtypes (pKi and pA2 estimates 7.7 - 7.8). Learn MoreStarting at: $135.00
-
MSPG
MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices. Learn MoreStarting at: $135.00
-
(2R,4R)-APDC
MSPG is a selatively non-selective antagonist of presynaptic mGlu receptors in neonatal rat spinal cord and adult rat cerebrocortical mGlu receptors. Learn MoreStarting at: $165.00
-
L-CCG-l
L-CCG-l is a potent group II metabotropic glutamate receptor agonist. Learn MoreStarting at: $185.00
