GABA Receptors
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Ro 19-4603
Ro 19-4603 is a benzodiazepine inverse agonist, which binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Learn MoreStarting at: $99.00
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GABA
GABA is an endogenous inhibitory neurotransmitter. Learn MoreStarting at: $45.00
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CGP 35348
CGP 35348 is a selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Learn MoreStarting at: $135.00
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CGP 46381
CGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM). Learn MoreStarting at: $135.00
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CGP 36216 hydrochloride
CGP 36216 hydrochloride is a selective GABAB antagonist, which displays activity at presynaptic receptors. Learn MoreStarting at: $130.00
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Saclofen
Saclofen is a selective antagonist at GABAB receptors. Learn MoreStarting at: $115.00
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SKF 97541
SKF 97541 is a very potent GABAB agonist, at least ten times more active than baclofen. Learn MoreStarting at: $115.00
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Pregnanolone
Pregnanolone is a GABAA receptor positive allosteric modulator. Learn MoreStarting at: $95.00
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N-ArachidonylGABA
N-ArachidonylGABA is a arachidonyl amino acid; first isolated from bovine brain. Learn MoreStarting at: $80.00
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L-655,708
L-655,708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM), which displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Learn MoreStarting at: $105.00
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PHP 501 trifluoroacetate
PHP 501 trifluoroacetate is a potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters. Learn MoreStarting at: $150.00
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rac BHFF
rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively), which exhibits anxiolytic activity in vivo and is orally active. Learn MoreStarting at: $95.00
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Valerenic acid
Valerenic acid is a positive allosteric modulator of GABAA receptors, which wdisplays preference for receptors containing β2 or β3 subunits and activates the receptor and also blocks the channel at high concentrations. Learn MoreStarting at: $85.00
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SR 95531 hydrobromide
SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist, which acts as a low affinity glycine receptor antagonist and displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Learn MoreStarting at: $85.00
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CGS 20625
CGS 20625 is a selective, partial agonist for the benzodiazepine binding site of the GABAA receptor which potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Learn MoreStarting at: $135.00
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(RS)-Baclofen
(RS)-Baclofen is a selective GABAB receptor agonist, as well as a Skeletal muscle relaxant. Learn MoreStarting at: $65.00
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Phaclofen
Phaclofen is a selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen. Learn MoreStarting at: $90.00
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Loreclezole hydrochloride
Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.It also inhibits homomeric ρ1 GABAC receptors. Learn MoreStarting at: $125.00
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DMCM hydrochloride
DMCM hydrochloride is a benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. Learn MoreStarting at: $110.00
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GBLD 345
GBLD 345 is a high affinity benzodiazepine agonist (IC50 against diazepam = 1 nM). Learn MoreStarting at: $100.00