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Enzymes
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CPT 11
CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Learn MoreStarting at: $139.00
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Ceranib 1
Ceranib 1 is a ceramidase inhibitor which inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM), and induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells. Learn MoreStarting at: $85.00
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TC HSD 21
TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Learn MoreStarting at: $109.00
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KH 7
KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo), which inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM, and locks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM. Learn MoreStarting at: $109.00
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MDL 12330A hydrochloride
MDL 12330A hydrochloride is an inhibitor of adenylyl cyclase, which also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells. Learn MoreStarting at: $85.00
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EBPC
EBPC is a potent aldose reductase inhibitor, which improves the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells through an increase in ERK activity. Learn MoreStarting at: $89.00
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4-HQN
4-HQN is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM), which displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Learn MoreStarting at: $69.00
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BYK 49187
Chromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM), which blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM). Learn MoreStarting at: $70.00
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Alrestatin
Alrestatin is a specific inhibitor of aldose reductase (IC50 = 148 μM). Learn MoreStarting at: $90.00
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Methylmalonate
Imethylmalonate intracellularly produces malonate and induces apoptotic cell death in striatal neurons. Learn MoreStarting at: $70.00
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L189
L189 is a DNA ligase I, III and IV inhibitor with IC50 values of 5, 9 and 5 μM respectively. Learn MoreStarting at: $119.00
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1,9-Dideoxyforskolin
1,9-Dideoxyforskolin is an inactive analog of forskolin. Learn MoreStarting at: $58.00
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TC-E 5001
TC-E 5001 is a dual tankyrase (TNKS) inhibitor that inhibits wnt signaling and stabilizes Axin2 levels. Learn MoreStarting at: $99.00
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NU 1025
NU 1025 is a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Learn MoreStarting at: $105.00
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Bromosporine
Bromosporine is a broad spectrum bromodomain inhibitor, which accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM. Learn MoreStarting at: $199.00
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DR 2313
DR 2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Learn MoreStarting at: $49.00
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Dexrazoxane hydrochloride
Dexrazoxane hydrochloride is a topoisomerase II inhibitor and intracellular ion chelator, which bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Learn MoreStarting at: $45.00
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S 32826
S 32826 is an inhibitor of autotaxin (IC50 = 9 nM), which displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ)and inhibits LPA release from adipocytes (IC50 = 90 nM). Learn MoreStarting at: $135.00
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BYK 204165
BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). Learn MoreStarting at: $95.00
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CI 976
CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM), which inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM). Learn MoreStarting at: $95.00
