Proteases
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PD 150606
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Learn MoreStarting at: $100.00
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N-Acetyl-L-leucyl-L-leucyl-L-methional
N-Acetyl-L-leucyl-L-leucyl-L-methional is a very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Learn MoreStarting at: $90.00
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L 006235
L 006235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Learn MoreStarting at: $159.00
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SID 26681509
SID 26681509 is a potent and reversible human cathepsin L inhibitor with an IC50 value of 56 nM. Learn MoreStarting at: $149.00
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Fumagillin
Fumagillin is an antibiotic and antiangiogenic agent, which covalently binds and inhibits methionine aminopeptidase-2. Learn MoreStarting at: $119.00
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Captopril
Captopril is a angiotensin-converting enzyme (ACE) inhibitor that also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase. Learn MoreStarting at: $38.00
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Moexipril hydrochloride
Moexipril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor that decreases mean blood pressure in the spontaneous hypertensive rat (SHR) and also blocks degradation of bradykinin into inactive metabolites. Learn MoreStarting at: $109.00
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ZJ 43
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). Learn MoreStarting at: $89.00
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PMPA (NAALADase inhibitor)
PMPA (NAALADase inhibitor) is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Learn MoreStarting at: $90.00
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NSC 687852
NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitylating enzymes (DUBs), UCHL5 and USP14. Learn MoreStarting at: $95.00
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NSC 632839 hydrochloride
5-Nonyloxytryptamine oxalate is a 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). Learn MoreStarting at: $85.00
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Vialinin A
Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity. Learn MoreStarting at: $65.00
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DPPI 1c hydrochloride
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) that increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge. Learn MoreStarting at: $85.00
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K 579
K 579 is a dipeptidyl peptidase IV inhibitor, which inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Learn MoreStarting at: $149.00
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NVP DPP 728 dihydrochloride
NVP DPP 728 dihydrochloride is a potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Learn MoreStarting at: $139.00
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PK 44 phosphate
PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Learn MoreStarting at: $195.00
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SSR 69071
SSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM), which displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively) and inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active. Learn MoreStarting at: $139.00
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Compound W
Compound W is an inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). Learn MoreStarting at: $55.00
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L-685,458
L-685,458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Learn MoreStarting at: $189.00
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JLK 6
JLK 6 is inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Learn MoreStarting at: $109.00