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ATPases/GTPases
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Xanthohumol
Xanthohumol is a Valosin-containing protein (VCP) inhibitor that binds to the N domain of VCP, suppressing function and impairing autophagosome maturation. Learn MoreStarting at: $139.00
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ITX 3
ITX 3 is a selective inhibitor of TrioN RhoGEF activity, which inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro. Learn MoreStarting at: $109.00
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MitMAB
MitMAB is a dynamin inhibitor, which inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Learn MoreStarting at: $50.00
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OctMAB
OctMAB is a dynamin inhibitor (IC50 = 1.9 μM for dynamin I) which inhibits receptor-mediated endocytosis (IC50 = 16 μM). Learn MoreStarting at: $50.00
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Dynole 34-2
Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM) and inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM). Learn MoreStarting at: $135.00
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Golgicide A
Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Learn MoreStarting at: $125.00
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8-pCPT-2-O-Me-cAMP-AM
8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog which induces Rap activation and junction tightening in HUVECs. Learn MoreStarting at: $150.00
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ML 141
ML 141 is an allosteric inhibitor of Cdc42 GTPase with selectivity for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Learn MoreStarting at: $139.00
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8-CPT-2Me-cAMP, sodium salt
8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Learn MoreStarting at: $125.00
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ARL 67156 trisodium salt
NU 2058 is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively), which inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM) and DNA topoisomerase II ATPase activity (IC50 = 300 μM). Learn MoreStarting at: $155.00
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PSB 06126
PSB 06126 is a nucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) inhibitor, which inhibits rat NTPDase 3 at low micromolar concentrations and display selectivity over NTPDase 1 and NTPDase 2. Learn MoreStarting at: $120.00
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PSB 069
PSB 069 is a non-selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor. Learn MoreStarting at: $109.00
