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Acetylcholine Nicotinic Receptors
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TQS
TQS is a type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Learn MoreStarting at: $125.00
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DMAB-anabaseine dihydrochloride
DMAB-anabaseine dihydrochloride is a partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Learn MoreStarting at: $119.00
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S 24795
S 24795 is a partial agonist of α7 nAChR, which improves mnemonic function in aged mice for the treatment of aging-related memory disturbances and displays more efficient memory-enhancing effects than memantine in Alzheimer's disease mouse models. Learn MoreStarting at: $90.00
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PHA 543613 hydrochloride
PHA 543613 hydrochloride is a potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors, which positively influences sensory gating and memory in in vivo models of schizophrenia. Learn MoreStarting at: $149.00
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NS 1738
NS 1738 is a selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Learn MoreStarting at: $99.00
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PHA 568487
PHA 568487 is an orally active and brain penetrant agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively). Learn MoreStarting at: $99.00
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AR-R 17779 hydrochloride
AR-R 17779 hydrochloride is a selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). Learn MoreStarting at: $140.00
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TC 1698 dihydrochloride
TC 1698 dihydrochloride is a selective nicotinic α7 receptor agonist that displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Learn MoreStarting at: $125.00
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MG 624
MG 624 inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively. Learn MoreStarting at: $99.00
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A 844606
A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist with EC50 values of 1.4 and 2.2 μM at human and rat receptors respectively. Learn MoreStarting at: $129.00
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SEN 12333
SEN 12333 is a α7 nicotinic acetylcholine receptor (nAChR) agonist that displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs with an IC50 value of 8.5 μM. Learn MoreStarting at: $125.00
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CCMI
CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR) that evokes positive modulation of acetylcholine (ACh)-induced EC5 currents. Learn MoreStarting at: $95.00
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LY 2087101
LY 2087101 is an allosteric potentiator of α7, α4β2 and α4β4 nAChRs. Learn MoreStarting at: $125.00
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Sazetidine A dihydrochloride
Sazetidine A dihydrochloride is a subtype-selective α4β2 nicotinic acetylcholine receptor ligand (Ki values are 0.26 and 54 nM at α4β2 and α3β4 receptors respectively). Learn MoreStarting at: $135.00
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Desformylflustrabromine hydrochloride
Desformylflustrabromine hydrochloride is a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors (nAChRs) which selectively increases the ionic current through α4β2 in the presence of ACh. Learn MoreStarting at: $119.00
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5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative is a precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380. Suitable for radioiodination. Learn MoreStarting at: $90.00
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5-Iodo-A-85380 dihydrochloride
5-Iodo-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors, which activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively. Learn MoreStarting at: $195.00
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TC 2559 difumarate
TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively), which displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Learn MoreStarting at: $130.00
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3-pyr-Cytisine
3-pyr-Cytisine is a high affinity α4β2 partial agonist that exhibits antidepressant-like effects in mouse models of antidepressant efficacy. Learn MoreStarting at: $139.00
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UB 165 fumarate
UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively. Learn MoreStarting at: $179.00
