Smoothened Receptors
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SMANT hydrochloride
SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism, which inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Learn MoreStarting at: $95.00
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MRT 10
MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo), which inhibits ShhN-induced Gli luciferase reporter activity in Shh-light2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells). Learn MoreStarting at: $119.00
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RuBi-GABA
RuBi-GABA is a Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths, which provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Learn MoreStarting at: $145.00