Sphingosine-1-Phosphate Receptors
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CYM 5442 hydrochloride
CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM), which induces acute lymphopenia in mice. Learn MoreStarting at: $135.00
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CS 2100
CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 value of 4.0 nM. Learn MoreStarting at: $169.00
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W146
W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist that enhances capillary leakage and restores lymphocyte egress in vivo. Learn MoreStarting at: $109.00
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JTE 013
JTE 013, a sphingosine-1-phosphate (S1P) receptor antagonist, inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. Learn MoreStarting at: $149.00
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VPC 23019
VPC 23019 is a sphingosine-1-phosphate receptor antagonist, which inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively). Learn MoreStarting at: $219.00
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Sphingosine-1-phosphate
Sphingosine-1-phosphate endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization, which acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Learn MoreStarting at: $119.00
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SEW 2871
SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Learn MoreStarting at: $69.00
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CYM 50260
CYM 50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM) which displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM. Learn MoreStarting at: $110.00
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CYM 50308
CYM 50308 is a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 values are 56 nM and 2100 nM for S1P4 and S1P5 receptors, respectively). Learn MoreStarting at: $150.00
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RP 001 hydrochloride
RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM), which induces internalization and polyubiquitination of S1P1 in vitro. Learn MoreStarting at: $155.00
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TC-SP 14
TC-SP 14 is a potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Learn MoreStarting at: $135.00
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CYM 5541
CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist that occupies a different space within the ligand binding pocket of S1P3 than S1P. Learn MoreStarting at: $115.00