Calcium-Activated Potassium (KCa) Channels

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  • 1-EBIO

    1-EBIO is an activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. And it also induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Learn More

    Starting at: $65.00

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  • UCL 2077

    UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. Learn More

    Starting at: $105.00

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  • CyPPA

    CyPPA is an activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels. Learn More

    Starting at: $115.00

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  • SKA 31

    SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Learn More

    Starting at: $85.00

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  • NS 6180

    NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively), which exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Learn More

    Starting at: $99.00

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  • BMS 191011

    BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Learn More

    Starting at: $120.00

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  • UCL 1684

    UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons) which blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively. Learn More

    Starting at: $119.00

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  • NS 1619

    NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator which induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM). Learn More

    Starting at: $145.00

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  • Penitrem A

    Penitrem A is a potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing α subunits only, and those containing α and β1 respectively), which blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo. Learn More

    Starting at: $75.00

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  • NS 11021

    NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Learn More

    Starting at: $139.00

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