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Search results for 'AP 24534'
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Bromosporine
Bromosporine is a broad spectrum bromodomain inhibitor, which accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM. Learn MoreStarting at: $199.00
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FPA 124
FPA 124 is an Akt/PKB inhibitor that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Learn MoreStarting at: $125.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
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SKF 86002 dihydrochloride
SKF 86002 dihydrochloride is an inhibitor of p38 MAP kinase that potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM) and also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells. Learn MoreStarting at: $149.00
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MRK 560
MRK 560 inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Learn MoreStarting at: $149.00
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(5Z)-7-Oxozeaenol
(5Z)-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Learn MoreStarting at: $109.00
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AEG 3482
AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling that binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Learn MoreStarting at: $89.00
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Captopril
Captopril is a angiotensin-converting enzyme (ACE) inhibitor that also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase. Learn MoreStarting at: $38.00
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JLK 6
JLK 6 is inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Learn MoreStarting at: $109.00
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PIT 1
PIT 1, a selective PIP3 antagonist, blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03;M) and also inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Learn MoreStarting at: $119.00
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Tris DBA
Tris DBA is a N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Learn MoreStarting at: $75.00
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Ambenonium dichloride
Ambenonium dichloride is a extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) with IC50 values =0.000698 and 8.20 μM at AChE and BChE respectively. Learn MoreStarting at: $99.00
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Methylmalonate
Imethylmalonate intracellularly produces malonate and induces apoptotic cell death in striatal neurons. Learn MoreStarting at: $70.00
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2-Iminopiperidine hydrochloride
SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Learn MoreStarting at: $70.00
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8-CPT-2Me-cAMP, sodium salt
8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Learn MoreStarting at: $125.00
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HI TOPK 032
HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor, which exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM). Learn MoreStarting at: $159.00
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AZM 475271
AZM 475271 is a src tyrosine kinase inhibitor, which reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Learn MoreStarting at: $179.00
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CMPD-1
CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of the two other known p38 substrates, MBP and ATF-2. Learn MoreStarting at: $119.00
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ACHP
ACHP is a IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively), which inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Learn MoreStarting at: $209.00
