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Search results for 'AP 24534'
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BTZO 1
BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM), which activates antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Learn MoreStarting at: $95.00
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MDL 28170
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B that rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Learn MoreStarting at: $65.00
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SNAP
SNAP is a stable analog of endogenous S-nitroso compounds. Learn MoreStarting at: $59.00
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Carbenoxolone disodium
Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. Learn MoreStarting at: $65.00
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Ro 106-9920
Ro 106-9920 is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6. Learn MoreStarting at: $109.00
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Withaferin A
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. It prevents NF-κB activation by inhibiting activation of IKKβ. Learn MoreStarting at: $90.00
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Pyrrolidinedithiocarbamate ammonium
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP. Learn MoreStarting at: $65.00
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17-DMAG hydrochloride
17-DMAG hydrochloride is a water-soluble analog of 17-AAG and geldanamycin, which binds the ATP binding site of Hsp90 and inhibits its chaperone activity, and displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively). Learn MoreStarting at: $159.00
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Exo1
Exo1 is a reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Learn MoreStarting at: $95.00
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JW 67
JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Learn MoreStarting at: $109.00
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DMPO
Water soluble nitric oxide spin trap; allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR). Learn MoreStarting at: $55.00
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MG 132
MG 132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM) which inhibits TNF-α-induced NF-κB activation and IκBα degradation. Learn MoreStarting at: $75.00
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D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt
D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt, as an important second messenger involved in Ca2+ mobilization from intracellular stores (EC50 = 0.1 μM), is formed from the enzymatic hydrolysis of phosphatidyl inositol-4,5-bisphosphate. . Learn MoreStarting at: $119.00
