Search results for 'mTOR'
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Plumbagin
Plumbagin is an anticancer agent, which induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Learn MoreStarting at: $39.00
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SMER 28
SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway, which increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's disease and Parkinson's disease, respectively. Learn MoreStarting at: $85.00
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10-DEBC hydrochloride
10-DEBC hydrochloride is a selective inhibitor of Akt/PKB, which inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Learn MoreStarting at: $90.00
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L-690,330
L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition. Learn MoreStarting at: $110.00
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PF 04691502
PF 04691502 is an potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Learn MoreStarting at: $145.00