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Search results for 'gsk'
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CHIR 99021 trihydrochloride
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021, a highly selective GSK-3 inhibitor. Learn MoreStarting at: $189.00
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Cesium chloride
Cesium chloride is a potassium channel blocker that prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β. Learn MoreStarting at: $39.00
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GSK 264220A
GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor with IC50 values of 0.13 and 0.10 μM respectively. Learn MoreStarting at: $119.00
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BIO-acetoxime
BIO-acetoxime is a selective GSK-3α/β inhibitor that induces Wnt signaling and inhibits CD8+ T cell effector differentiation. Learn MoreStarting at: $89.00
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BIO
BIO is a potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor that maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro and also promotes proliferation and dedifferentiation in cardiomyocytes. Learn MoreStarting at: $109.00
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DMP 543
Indirubin-3'-oxime is aprotein kinase inhibitor and inhibits cyclin-dependent kinases (IC50 = 0.18 - 3.33 μM) and GSK-3β (IC50 = 0.19 μM). Learn MoreStarting at: $95.00
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BIBP 3226 trifluoroacetate
3F8 is a potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively). Learn MoreStarting at: $90.00
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JW 67
JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Learn MoreStarting at: $109.00
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NSC 693868
NSC 693868 is an inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. Learn MoreStarting at: $139.00
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GSK 3787
GSK 3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6), which displays no measurable affinity for PPARα or PPARγ in vitro (pIC50< 5). Learn MoreStarting at: $69.00
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A 1070722
A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) which displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Learn MoreStarting at: $135.00
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TCS 21311
TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM), which inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively). Learn MoreStarting at: $155.00
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GSK 789472 hydrochloride
GSK 789472 hydrochloride is a selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively), which selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant. Learn MoreStarting at: $95.00
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TC-G 24
TC-G 24 is a potent GSK-3β inhibitor (IC50 = 17 nM), which displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Learn MoreStarting at: $135.00
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SR 8278
SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM) and blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. Learn MoreStarting at: $115.00
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Ro 31-8220 mesylate
Ro 31-8220 mesylate is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Learn MoreStarting at: $95.00
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GSK 9027
GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8), which inhibits production of the proinflammatory mediator IL-6 in vivo. Learn MoreStarting at: $135.00
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GSK 4112
GSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM) which enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Learn MoreStarting at: $100.00
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GSK 4716
GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERR&gamma, which displays selectivity over ERRα and the classical estrogen receptors. Learn MoreStarting at: $63.00
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TCS 2002
TCS 2002 is a potent inhibitor of GSK-3β (IC50 = 35 nM), that inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. Learn MoreStarting at: $129.00
