Angiogenesis
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Chetomin
Chetomin targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro. Learn MoreStarting at: $125.00
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ML 228
ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM. Learn MoreStarting at: $135.00
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DMPQ dihydrochloride
DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM) which displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C. Learn MoreStarting at: $95.00
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SU 16f
SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Learn MoreStarting at: $140.00
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SU 4312
SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Learn MoreStarting at: $189.00
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DMH4
DMH4 is a selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Learn MoreStarting at: $140.00
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RuBi-Glutamate
RuBi-Glutamate is a Ruthenium-bipyridine-triphenylphosphine caged glutamate that can be excited by visible wavelengths and releases glutamate after one- or two-photon excitation. Learn MoreStarting at: $149.00
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Linomide
Linomide is an immunomodulator with stimulatory and antitumor properties. Learn MoreStarting at: $125.00
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OGT 2115
OGT 2115 is a heparanase inhibitor that displays no major inhibition of human cytochrome P450 isoenzymes. Learn MoreStarting at: $59.00