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Acetylcholine Nicotinic Receptors
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UB 165 fumarate
UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively. Learn MoreStarting at: $179.00
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SIB 1553A hydrochloride
SIB 1553A hydrochloride is a nicotinic acetylcholine receptor (nAChR) agonist which displays selectivity for β4 subunit-containing receptors. Learn MoreStarting at: $105.00
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SR 16584
SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM), which selectively binds α3β4 over α4β2 and α7 subtypes (Ki values are 0.508, >100 and >100 μM, respectively). Learn MoreStarting at: $125.00
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(+)-Tubocurarine chloride
(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist and also is a 5-HT3 and GABAA receptor antagonist. Learn MoreStarting at: $43.00
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1-Acetyl-4-methylpiperazine hydrochloride
1-Acetyl-4-methylpiperazine hydrochloride is a structural analog of acetylcholine that acts as a nAChR agonist. Learn MoreStarting at: $96.00
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(±)-Anatoxin A fumarate
(±)-Anatoxin A fumarate is a potent nicotinic agonist that stimulates [3H]-dopamine release from rat striatal synaptosomes with EC50 value of 136 nM. Learn MoreStarting at: $139.00
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Chlorisondamine diiodide
Chlorisondamine diiodide is an exceptionally long lasting nicotinic antagonist with IC50 value of ~1.6 mM. Learn MoreStarting at: $99.00
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4-Acetyl-1,1-dimethylpiperazinium iodide
4-Acetyl-1,1-dimethylpiperazinium iodide is a structural analog of acetylcholine that acts as a nicotinic agonist with a Ki value of 29.9 nM at α4β2. Learn MoreStarting at: $89.00
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Mecamylamine hydrochloride
Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist that displays antidepressant-like effects in mice. Learn MoreStarting at: $75.00
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TMPH hydrochloride
TMPH hydrochloride is a potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Learn MoreStarting at: $95.00
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RJR 2429 dihydrochloride
RJR 2429 dihydrochloride is a potent nAChR agonist that displays selectivity for α4β2 and α1βγδ. Learn MoreStarting at: $109.00
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Hexamethonium bromide
Hexamethonium bromide is a Nicotinic receptor (nAChR) blocker at autonomic ganglia that induces changes in neuronal activity similar to the influences of glutamate in vitro. Learn MoreStarting at: $20.00
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(+)-Anabasine hydrochloride
(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist. It stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro. Learn MoreStarting at: $72.00
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RuBi-Nicotine
Ruthenium-bisbipyridine-caged nicotine, excitable by irradiation with visible light, which exhibits a high quantum yield. Induces action potential propagation in Retzius neurons of leech ganglia with no detectable toxicity at a concentration of 1 mM. Learn MoreStarting at: $299.00
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(-)-Lobeline hydrochloride
(-)-Lobeline hydrochloride is a high affinity nicotinic receptor ligand, with a Ki value of 4.4 nM in rat brain. Learn MoreStarting at: $55.00
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(±)-Epibatidine
(±)-Epibatidine is a very potent nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Learn MoreStarting at: $180.00
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3-Bromocytisine
3-Bromocytisine is a potent agonist of α4β4, α4β2 and α7 nACh receptors (IC50 values are 0.28, 0.30 and 31.6 nM respectively), which displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC50 values are 0.008 and 0.05 μM respectively). Learn MoreStarting at: $140.00
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Benzoquinonium dibromide
Benzoquinonium dibromide is a nicotinic antagonist, ganglion blocker, which activates single channels but blocks open channels at nicotinic receptors. Learn MoreStarting at: $90.00
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(-)-Cotinine
Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum, and displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model. Learn MoreStarting at: $65.00
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Carbamoylcholine chloride
Carbamoylcholine chloride is a cholinergic receptor agonist that is resistant to the action of cholinesterases. Learn MoreStarting at: $59.00
