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5-HT Receptors
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Ipsapirone
Ipsapirone is a selective 5-HT1A receptor agonist with a Ki value of 10 nM. Learn MoreStarting at: $99.00
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EMD 281014 hydrochloride
EMD 281014 hydrochloride is a selective 5-HT2A antagonist; displays high affinity for human 5-HT2A over 5-HT2C receptors (Ki values are 0.87 and 557 nM respectively). Learn MoreStarting at: $115.00
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DOI hydrochloride
Brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively), which reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Learn MoreStarting at: $90.00
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Cyanopindolol hemifumarate
Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist. Learn MoreStarting at: $99.00
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MDL 11,939
MDL 11,939 is an Orally active 5-HT2A receptor antagonist, which displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively). Learn MoreStarting at: $105.00
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Altanserin hydrochloride
Altanserin hydrochloride is a potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Learn MoreStarting at: $95.00
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MDL 72832 hydrochloride
MDL 72832 hydrochloride is a potent ligand at 5-HT1A receptors, with mixed agonist and antagonist properties. Learn MoreStarting at: $90.00
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MDL 73005EF hydrochloride
MDL 73005EF hydrochloride is a potent and selective 5-HT1A receptor antagonist, which has partial agonist properties. Learn MoreStarting at: $90.00
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Fananserin
Fananserin is a 5-HT2A receptor antagonist that also displays high affinity at D4 receptors (Ki values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1, α1, 5-HT1A and D2 receptors respectively). Learn MoreStarting at: $95.00
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DV 7028 hydrochloride
DV 7028 hydrochloride is a selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Learn MoreStarting at: $105.00
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Sarpogrelate hydrochloride
Sarpogrelate hydrochloride is a selective 5-HT2A receptor antagonist (pKi values are 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively), which displays selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Learn MoreStarting at: $100.00
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Buspirone hydrochloride
Buspirone hydrochloride is a classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). Learn MoreStarting at: $49.00
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Zotepine
Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Learn MoreStarting at: $65.00
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AT 1015
AT 1015 is a long-acting 5-HT2A receptor antagonist which inhibits vasoconstriction and blocks platelet aggregation. Learn MoreStarting at: $115.00
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(S)-WAY 100135 dihydrochloride
(S)-WAY 100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Learn MoreStarting at: $110.00
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4F 4PP oxalate
4F 4PP oxalate is a selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM). Learn MoreStarting at: $98.00
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S 14506 hydrochloride
S 14506 hydrochloride is a highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Learn MoreStarting at: $135.00
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CJ 033466
CJ 033466 is a potent and selective 5-HT4 partial agonist (EC50= 0.927 nM) with > 1000-fold selectivity for 5-HT4 over other 5-HT and D2 receptors. Learn MoreStarting at: $119.00
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RS 67506 hydrochloride
(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Learn MoreStarting at: $90.00
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RS 67333 hydrochloride
RS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Learn MoreStarting at: $95.00
