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Voltage-gated Sodium (NaV) Channels
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Mexiletine hydrochloride
Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Learn MoreStarting at: $49.00
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Veratridine
Veratridine is a Voltage-gated Na+ channel opener that increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Learn MoreStarting at: $79.00
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Flecainide acetate
Flecainide acetate is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Learn MoreStarting at: $45.00
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Vinpocetine
Vinpocetine is a phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM), which also blocks voltage-gated Na+ channels. Learn MoreStarting at: $109.00
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Licarbazepine
Licarbazepine is an active metabolite of oxcarbazepine which produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Learn MoreStarting at: $85.00
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Ambroxol hydrochloride
Ambroxol hydrochloride is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties, which inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Learn MoreStarting at: $69.00
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QX 314 bromide
QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Learn MoreStarting at: $85.00
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QX 222
QX 222 is a sodium channel blocker. Learn MoreStarting at: $50.00
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Ralfinamide mesylate
Ralfinamide mesylate is a sodium channel blocker, which suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Learn MoreStarting at: $65.00
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Amiloride hydrochloride
Amiloride hydrochloride is Na+ channel blocker, which defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding sites. Learn MoreStarting at: $55.00
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Tetrodotoxin citrate
Tetrodotoxin citrate is a highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin. Learn MoreStarting at: $139.00
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KC 12291 hydrochloride
KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker which inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Learn MoreStarting at: $135.00
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Co 102862
Co 102862 is a broad spectrum, state-dependent blocker of voltage-gated sodium channels which displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Learn MoreStarting at: $95.00
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Sipatrigine
Sipatrigine is a blocker of voltage-dependent sodium channels (NaV) which inhibits glutamate release and displays neuroprotective activity in rat models of cerebral ischemia. Learn MoreStarting at: $145.00
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A 887826
A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Learn MoreStarting at: $135.00
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TC-N 1752
TC-N 1752 is a selective blocker of human NaV1.7 channels (IC50 values are 0.17, 0.3, 0.4 and 1.1 μM at hNaV1.7, hNaV1.3, hNaV1.4 and hNaV1.5 respectively), which also displays analgesic efficacy in the formalin pain model and inhibits tetrodotoxin-sensitive sodium channels. Learn MoreStarting at: $155.00
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ML 298 hydrochloride
ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively), which decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability. Learn MoreStarting at: $125.00
