Transporters
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Escitalopram oxalate
Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI) (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Learn MoreStarting at: $55.00
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Lofepramine
Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine, which produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo. Learn MoreStarting at: $90.00
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Dexfenfluramine hydrochloride
Dexfenfluramine hydrochloride is an indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Learn MoreStarting at: $49.00
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WY 45233 succinate
WY 45233 succinate is a serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Learn MoreStarting at: $149.00
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Amitriptyline hydrochloride
Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenalin uptake and also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Learn MoreStarting at: $32.00
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Fluoxetine hydrochloride
Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. It binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Learn MoreStarting at: $69.00
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Reversan
Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Learn MoreStarting at: $139.00
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XR 9051 HCl
XR 9051 HCl is a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) that inhibits the binding of cytotoxics to P-glycoprotein (EC50 = 134 nM). Learn MoreStarting at: $135.00
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Elacridar hydrochloride
P-glycoprotein (P-gp/ABCG1) inhibitor, which blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. It also inhibits breast cancer resistance protein (BCRP/ABCG2). Learn MoreStarting at: $100.00
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CP 100356 hydrochloride
CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms) which inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Learn MoreStarting at: $155.00
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Fumitremorgin C
Fumitremorgin is a chemosensitizing agent which selectively reverses BCRP-mediated multidrug resistance. Learn MoreStarting at: $170.00
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(±)-Vesamicol hydrochloride
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM), which centrally active following systemic administration in vivo. Learn MoreStarting at: $69.00
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Concanamycin A
Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. Learn MoreStarting at: $99.00
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Talopram hydrochloride
Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) with selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Learn MoreStarting at: $139.00
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Bicifadine hydrochloride
Bicifadine hydrochloride is an orally active, potent antagonist of the noradrenalin transporter with antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Learn MoreStarting at: $139.00
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Desipramine hydrochloride
Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters with Ki values of 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively. Learn MoreStarting at: $41.00
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Talsupram hydrochloride
Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor which exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Learn MoreStarting at: $129.00
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(-)-5'-DMH-CBD
(-)-5'-DMH-CBD is an anandamide membrane transport inhibitor (IC50 = 14 μM) that is relatively metabolically stable, which displays some affinity for CB2 receptors but has only weak affinity for CB1 receptors and has no activity at VR1 receptors or FAAH. Learn MoreStarting at: $149.00
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YM 244769
YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX) that inhibits Na+-dependent 45Ca2+ uptake with IC50 values of 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively. Learn MoreStarting at: $125.00
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CGP 37157
CGP 37157 is a selective antagonist of the mitochondrial Na+-Ca2+ exchanger with an IC50 of 0.4 μM. Learn MoreStarting at: $139.00