Transporters

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  • Escitalopram oxalate

    Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI) (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Learn More

    Starting at: $55.00

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  • Lofepramine

    Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine, which produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo. Learn More

    Starting at: $90.00

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  • Dexfenfluramine hydrochloride

    Dexfenfluramine hydrochloride is an indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Learn More

    Starting at: $49.00

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  • WY 45233 succinate

    WY 45233 succinate is a serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Learn More

    Starting at: $149.00

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  • Amitriptyline hydrochloride

    Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenalin uptake and also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Learn More

    Starting at: $32.00

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  • Fluoxetine hydrochloride

    Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. It binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Learn More

    Starting at: $69.00

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  • Reversan

    Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Learn More

    Starting at: $139.00

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  • XR 9051 HCl

    XR 9051 HCl is a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) that inhibits the binding of cytotoxics to P-glycoprotein (EC50 = 134 nM). Learn More

    Starting at: $135.00

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  • Elacridar hydrochloride

    P-glycoprotein (P-gp/ABCG1) inhibitor, which blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. It also inhibits breast cancer resistance protein (BCRP/ABCG2). Learn More

    Starting at: $100.00

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  • CP 100356 hydrochloride

    CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms) which inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Learn More

    Starting at: $155.00

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  • Fumitremorgin C

    Fumitremorgin is a chemosensitizing agent which selectively reverses BCRP-mediated multidrug resistance. Learn More

    Starting at: $170.00

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  • (±)-Vesamicol hydrochloride

    (±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM), which centrally active following systemic administration in vivo. Learn More

    Starting at: $69.00

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  • Concanamycin A

    Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. Learn More

    Starting at: $99.00

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  • Talopram hydrochloride

    Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) with selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Learn More

    Starting at: $139.00

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  • Bicifadine hydrochloride

    Bicifadine hydrochloride is an orally active, potent antagonist of the noradrenalin transporter with antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Learn More

    Starting at: $139.00

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  • Desipramine hydrochloride

    Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters with Ki values of 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively. Learn More

    Starting at: $41.00

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  • Talsupram hydrochloride

    Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor which exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Learn More

    Starting at: $129.00

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  • (-)-5'-DMH-CBD

    (-)-5'-DMH-CBD is an anandamide membrane transport inhibitor (IC50 = 14 μM) that is relatively metabolically stable, which displays some affinity for CB2 receptors but has only weak affinity for CB1 receptors and has no activity at VR1 receptors or FAAH. Learn More

    Starting at: $149.00

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  • YM 244769

    YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX) that inhibits Na+-dependent 45Ca2+ uptake with IC50 values of 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively. Learn More

    Starting at: $125.00

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  • CGP 37157

    CGP 37157 is a selective antagonist of the mitochondrial Na+-Ca2+ exchanger with an IC50 of 0.4 μM. Learn More

    Starting at: $139.00

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