Transient Receptor Potential Channels

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  • RN 1747

    RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively) which displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Learn More

    Starting at: $95.00

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  • SB 366791

    SB 366791 is a potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Learn More

    Starting at: $109.00

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  • α-Spinasterol

    α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM), which reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Learn More

    Starting at: $89.00

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  • 5'-Iodoresiniferatoxin

    5'-Iodoresiniferatoxin is a potent and silent vanilloid receptor antagonist that binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM. Learn More

    Starting at: $269.00

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  • AMG 9810

    AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Learn More

    Starting at: $119.00

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  • Olvanil

    Olvanil, a potent vanilloid receptor agonist, blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Learn More

    Starting at: $99.00

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  • JNJ 17203212

    JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that inhibits capsaicin- and H+-induced channel activation and exhibits antitussive and analgesic activity in vivo. Learn More

    Starting at: $119.00

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  • A 784168

    A 784168 is a potent TRPV1 antagonist with an IC50 value of 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin. Learn More

    Starting at: $139.00

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  • 6-Iodonordihydrocapsaicin

    6-Iodonordihydrocapsaicin is a potent competitive vanilloid TRPV1 (VR1) receptor antagonist that inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro. Learn More

    Starting at: $115.00

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  • HC 067047

    HC 067047 is a potent and selective TRPV4 antagonist that reversibly inhibits currents through mouse, human and rat TRPV4 orthologs. Learn More

    Starting at: $139.00

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  • SB 452533

    SB 452533 is a potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Learn More

    Starting at: $109.00

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  • RN 1734

    RN 1734 is a selective TRPV4 antagonist with IC50 values of 2.3, 5.9 and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4 receptors respectively. Learn More

    Starting at: $95.00

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  • BCTC

    BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist, which inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Learn More

    Starting at: $109.00

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  • 6'-Iodoresiniferatoxin

    6'-Iodoresiniferatoxin is a high affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1), which displays partial agonism at human VR1 and full agonism at rat VR1. Learn More

    Starting at: $159.00

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  • OLDA

    OLDA is a potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Learn More

    Starting at: $75.00

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  • PPAHV

    PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM) that displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Learn More

    Starting at: $98.00

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  • PALDA

    PALDA is an endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Learn More

    Starting at: $75.00

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  • Polygodial

    Polygodial is a TRPA1 channel activator that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Learn More

    Starting at: $119.00

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  • AP 18

    AP 18 is a Reversible TRPA1 channel blocker with IC50 values of 3.1 and 4.5 μM at human and mouse TRPA1 respectively. Learn More

    Starting at: $90.00

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  • Pyr3

    Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3), which Inhibits hypertrophic responses in cardiomyocyte and TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM). Learn More

    Starting at: $100.00

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