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Signal Transduction
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Ionomycin calcium salt
Ionomycin is a calcium ionophore. Learn MoreStarting at: $99.00
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Ro 106-9920
Ro 106-9920 is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6. Learn MoreStarting at: $109.00
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Macbecin I
Macbecin I is an ensamycin antibiotic compound that inhibits Hsp90 activity by binding to the ATP-binding site. Learn MoreStarting at: $199.00
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CID 2858522
CID 2858522 selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway and inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Learn MoreStarting at: $109.00
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ML 130
ML 130 is a potent and selective inhibitor of NOD1 that inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Learn MoreStarting at: $119.00
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(-)-Xestospongin C
(-)-Xestospongin C is a highly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release with an IC50 value of 358 nM. Learn MoreStarting at: $149.00
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ODQ
ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase. Learn MoreStarting at: $79.00
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NPC 15199
NPC 15199 is an anti-inflammatory agent; increases intracellular Ca2+ levels. Learn MoreStarting at: $59.00
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2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine is a GTP cyclohydrolase I (GCH1) inhibitor, which exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein). Learn MoreStarting at: $69.00
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DHBP dibromide
DHBP dibromide is a blocks calcium release from sarcoplasmic reticulum by direct interaction with the ryanodine receptor. Learn MoreStarting at: $55.00
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D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt
D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt, as an important second messenger involved in Ca2+ mobilization from intracellular stores (EC50 = 0.1 μM), is formed from the enzymatic hydrolysis of phosphatidyl inositol-4,5-bisphosphate. . Learn MoreStarting at: $119.00
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cis-Ned 19
cis-Ned 19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist, which inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Learn MoreStarting at: $195.00
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trans-Ned 19
trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist, which inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and [32P]NAADP binding (IC50 = 0.4 nM). Learn MoreStarting at: $210.00
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Dantrolene, sodium salt
Dantrolene, sodium salt is an inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels which displays selectivity for RYR1 and RYR3 over RYR2. Learn MoreStarting at: $55.00
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Carboxy-PTIO, potassium salt
Carboxy-PTIO, potassium salt is a stable, water-soluble free radical that reacts stoichiometrically with NO. Learn MoreStarting at: $90.00
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CCT 018159
CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC50 = 5.7 μM) that displays selectivity over human Hsp72 and topoisomerase II. Learn MoreStarting at: $98.00
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Cardamonin
Cardamonin is a chalone analog that display anti-inflammatory activity. Learn MoreStarting at: $110.00
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Gedunin
Gedunin naturally occurring Hsp90 inhibitor, which induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Learn MoreStarting at: $139.00
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N-Methyllidocaine iodide
Antiarrhythmic. Enhances the biosynthesis of phosphatidylinositol in hamster heart. Learn MoreStarting at: $90.00
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DMPO
Water soluble nitric oxide spin trap; allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR). Learn MoreStarting at: $55.00
