Receptor Tyrosine Kinases (RTKs)
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BDNF (human)
BDNF (human) is a member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors which enhances the survival, growth and differentiation of neurons. Learn MoreStarting at: $239.00
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GW 441756
GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM), whih displays > 100-fold selectivity over a range of other kinases. Learn MoreStarting at: $139.00
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7,8-Dihydroxyflavone
7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). It inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Learn MoreStarting at: $119.00
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LM 22A4
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM), which induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome. Learn MoreStarting at: $129.00
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Ro 08-2750
Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change, which inhibits binding selectively to p75NTR at submicromolar concentrations and to both p75NTR and TrkA at higher concentrations (> 5 μM). Learn MoreStarting at: $69.00
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ANA 12
ANA 12 is a TrkB receptor antagonist, which demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Learn MoreStarting at: $135.00
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PF 04217903 mesylate
PF 04217903 mesylate is a highly selective, high affinity c-Met inhibitor that displays >1000-fold selectivity for c-Met over a panel of 208 kinases. Learn MoreStarting at: $189.00
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GTP 14564
GTP 14564 is a potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Learn MoreStarting at: $99.00
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5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) that displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma). Learn MoreStarting at: $119.00
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Demethylasterriquinone B1
Demethylasterriquinone B1 is a selective insulin receptor (IR) activator/mimetic that increases IR β subunit tyrosine phosphorylation and downstream activation of PI 3-kinase and Akt, but not ERK. Learn MoreStarting at: $169.00