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Proteases
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Cilastatin sodium
Cilastatin sodium is a dipeptidase inhibitor that inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Learn MoreStarting at: $89.00
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Nafamostat mesylate
Nafamostat mesylate is a broad spectrum serine protease inhibitor that reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Learn MoreStarting at: $45.00
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Butabindide oxalate
Butabindide oxalate is a potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Learn MoreStarting at: $135.00
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UAMC 00039 dihydrochloride
UAMC 00039 dihydrochloride is potent inhibitor of dipeptidyl peptidase II (DPP-II) with selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV. Learn MoreStarting at: $169.00
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Y-29794 oxalate
Y-29794 oxalate is an inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Learn MoreStarting at: $140.00
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CGS 35066
CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Learn MoreStarting at: $179.00
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4-Chlorophenylguanidine hydrochloride
4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of urokinase. Learn MoreStarting at: $120.00
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BC 11 hydrobromide
BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM), which exhibits no activity at 8 other related enzymes, and inhibits clot lysis with no effect on clot formation. Learn MoreStarting at: $105.00
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MRK 560
MRK 560 inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Learn MoreStarting at: $149.00
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L-685,458
L-685,458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Learn MoreStarting at: $189.00
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JLK 6
JLK 6 is inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Learn MoreStarting at: $109.00
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Compound W
Compound W is an inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). Learn MoreStarting at: $55.00
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SSR 69071
SSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM), which displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively) and inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active. Learn MoreStarting at: $139.00
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NVP DPP 728 dihydrochloride
NVP DPP 728 dihydrochloride is a potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Learn MoreStarting at: $139.00
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DPPI 1c hydrochloride
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) that increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge. Learn MoreStarting at: $85.00
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K 579
K 579 is a dipeptidyl peptidase IV inhibitor, which inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Learn MoreStarting at: $149.00
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PK 44 phosphate
PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Learn MoreStarting at: $195.00
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Vialinin A
Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity. Learn MoreStarting at: $65.00
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NSC 632839 hydrochloride
5-Nonyloxytryptamine oxalate is a 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). Learn MoreStarting at: $85.00
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NSC 687852
NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitylating enzymes (DUBs), UCHL5 and USP14. Learn MoreStarting at: $95.00
