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Peptide Receptors
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CGP 71683 hydrochloride
Extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Learn MoreStarting at: $139.00
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BIBO 3304 trifluoroacetate
BIBO 3304 trifluoroacetate is a high affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Learn MoreStarting at: $215.00
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BMS 193885
BMS 193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Learn MoreStarting at: $168.00
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PD 160170
PD 160170 is a potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Learn MoreStarting at: $110.00
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CYM 9484
CYM 9484 is a potent neuropeptide Y (NPY) Y2 receptor antagonist (IC50 = 19 nM). Learn MoreStarting at: $140.00
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SHA 68
SHA 68 is a selective neuropeptide S receptor (NPSR) antagonist with IC50 values of 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively. Learn MoreStarting at: $139.00
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L-368,899 hydrochloride
L-368,899 hydrochloride is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Learn MoreStarting at: $90.00
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L-371,257
RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells). Learn MoreStarting at: $155.00
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WAY 267464 dihydrochloride
WAY 267464 dihydrochloride is a potent, selective non-peptide oxytocin receptor (OTR) agonist. Learn MoreStarting at: $189.00
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AC 55541
AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist that stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro and exhibits pronociceptive activity in vivo. Learn MoreStarting at: $149.00
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Gabexate mesylate
Gabexate mesylate is a serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively).Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Learn MoreStarting at: $99.00
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RWJ 56110
RWJ 56110 is a selective protease-activated receptor-1 (PAR1) antagonist which displays no activity at PAR2, PAR3, or PAR4 subtypes and blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Learn MoreStarting at: $119.00
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FR 171113
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist which exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM). Learn MoreStarting at: $140.00
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Q94 hydrochloride
Q94 hydrochloride is a PAR1 negative allosteric modulator (IC50 = 916 nM); which inhibits PAR1-Gαq interaction. Learn MoreStarting at: $85.00
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NNC 26-9100
NNC 26-9100 is a somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Learn MoreStarting at: $155.00
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(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively). Learn MoreStarting at: $85.00
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L-803,087 trifluoroacetate
L-803,087 trifluoroacetate is a potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Learn MoreStarting at: $209.00
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L-817,818
L-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively which inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro. Learn MoreStarting at: $209.00
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Taltirelin
Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog which displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Learn MoreStarting at: $69.00
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SB 611812
SB 611812 is an urotensin-II (UT) antagonist, which inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Learn MoreStarting at: $139.00
