Peptide Receptors

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  • L-732,138

    L-732,138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM). Learn More

    Starting at: $65.00

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  • L-733,060 hydrochloride

    L-733,060 hydrochloride is a potent antagonist of human tachykinin NK1 receptors (Ki values are 0.08, 0.2 and 93.13 nM for gerbil, human and rat receptors respectively) which produces anxiolytic-like effects in the gerbil elevated plus-maze. Learn More

    Starting at: $140.00

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  • SB 218795

    SB 218795 is a potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3) which displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Learn More

    Starting at: $140.00

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  • SB 222200

    SB 222200 is a potent and selective non-peptide NK3 receptor antagonist. Ki values are 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors respectively. Learn More

    Starting at: $90.00

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  • SB 223412

    SB 223412 is a potent and selective non-peptide NK3 receptor antagonist (Ki values are 1, 144 and >100000 nM for human NK3, NK2 and NK1 receptors respectively). Learn More

    Starting at: $120.00

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  • SSR 146977 hydrochloride

    SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively), which also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM). Learn More

    Starting at: $169.00

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  • LY 288513

    LY 288513 is a selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively) which displays anxiolytic and antipsychotic properties in vivo. Learn More

    Starting at: $195.00

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  • YM 022

    YM 022 is an extremely potent and highly selective non-peptide CCK2 silent antagonist (Ki values are 68 pM and 63 nM at CCK2 and CCK1 receptors respectively). Learn More

    Starting at: $135.00

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  • LY 225910

    LY 225910 is a potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes). Learn More

    Starting at: $105.00

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  • CI 988

    CI 988 is a potent and selective CCK2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors (IC50 values are 1.7 and 2717 nM for CCK2 and CCK1 respectively). Learn More

    Starting at: $175.00

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  • PD 135158

    PD 135158 is a potent and selective, nonpeptide CCK2 receptor antagonist (IC50 values are 2.8 and 1232 nM for CCK2 and CCK1 respectively) that displays negligible affinity at GABAA, benzodiazepine, substance P, neurotensin, opioid, bradykinin and 5-HT3 receptors (IC50 > 10 μM). Learn More

    Starting at: $175.00

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  • L-365,260

    L-365,260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors. Learn More

    Starting at: $135.00

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  • ML 221

    ML 221 is an apelin receptor (APJ) antagonist with IC50 values of 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Learn More

    Starting at: $139.00

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  • TCS OX2 29

    TCS OX2 29 is a potent orexin 2 receptor (OX2) antagonist (IC50 = 40 nM) that displays > 250 fold selectivity over OX1 and over 50 other receptors, ion channels and transporters. Learn More

    Starting at: $139.00

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  • GR 159897

    SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92) which displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). Learn More

    Starting at: $140.00

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  • PD 176252

    PD 176252 is a non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively), which inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Learn More

    Starting at: $189.00

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  • WIN 64338 hydrochloride

    L-NIL hydrochloride is the first potent, non-peptide, competitive bradykinin B2 receptor antagonist. Learn More

    Starting at: $110.00

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  • SB 268262

    SB 268262 is a selective non-peptide CGRP1 antagonist which inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively). Learn More

    Starting at: $155.00

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  • SUN-B 8155

    SUN-B 8155 is a non-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC50 = 21 μM). Learn More

    Starting at: $109.00

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  • FPR A14

    FPR A14 is a formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Learn More

    Starting at: $119.00

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