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Peptide Receptors
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SR 49059
SR 49059 is a potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity, which displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors. Learn MoreStarting at: $225.00
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OPC 21268
OPC 21268 is a nonpeptide vasopressin V1 receptor antagonist, which displays greater affinity for rat V1 than human V1 (Ki values are 25 and 8800 nM respectively). Learn MoreStarting at: $150.00
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SB 657510
SB 657510 is a selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively), which inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM). Learn MoreStarting at: $139.00
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SB 706375
SB 706375 is a high affinity, non-peptide antagonist of the urotensin-II (UT) receptor with high affinity for mammalian UT receptors, including human, mouse and rat (Ki values are 9.3, 19.1 and 20.7 nM respectively, in HEK293 cells expressing recombinant UT receptors). Learn MoreStarting at: $139.00
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(±)-AC 7954 hydrochloride
(±)-AC 7954 hydrochloride is a highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively). Learn MoreStarting at: $139.00
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SB 611812
SB 611812 is an urotensin-II (UT) antagonist, which inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Learn MoreStarting at: $139.00
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Taltirelin
Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog which displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Learn MoreStarting at: $69.00
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L-803,087 trifluoroacetate
L-803,087 trifluoroacetate is a potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Learn MoreStarting at: $209.00
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L-817,818
L-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively which inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro. Learn MoreStarting at: $209.00
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(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively). Learn MoreStarting at: $85.00
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NNC 26-9100
NNC 26-9100 is a somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Learn MoreStarting at: $155.00
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RWJ 56110
RWJ 56110 is a selective protease-activated receptor-1 (PAR1) antagonist which displays no activity at PAR2, PAR3, or PAR4 subtypes and blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Learn MoreStarting at: $119.00
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Gabexate mesylate
Gabexate mesylate is a serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively).Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Learn MoreStarting at: $99.00
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FR 171113
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist which exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM). Learn MoreStarting at: $140.00
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AC 55541
AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist that stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro and exhibits pronociceptive activity in vivo. Learn MoreStarting at: $149.00
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Q94 hydrochloride
Q94 hydrochloride is a PAR1 negative allosteric modulator (IC50 = 916 nM); which inhibits PAR1-Gαq interaction. Learn MoreStarting at: $85.00
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WAY 267464 dihydrochloride
WAY 267464 dihydrochloride is a potent, selective non-peptide oxytocin receptor (OTR) agonist. Learn MoreStarting at: $189.00
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L-371,257
RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells). Learn MoreStarting at: $155.00
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L-368,899 hydrochloride
L-368,899 hydrochloride is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Learn MoreStarting at: $90.00
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SHA 68
SHA 68 is a selective neuropeptide S receptor (NPSR) antagonist with IC50 values of 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively. Learn MoreStarting at: $139.00
