P53

7 Item(s)

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  • RETRA hydrochloride

    RETRA hydrochloride is an antitumor agent, that inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Learn More

    Starting at: $95.00

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  • CP 31398 dihydrochloride

    CP 31398 dihydrochloride is a p53 stabilizing agent, which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53 and inhibits growth of small human tumor xenografts in vivo. Learn More

    Starting at: $90.00

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  • WR 1065

    WR 1065 is a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway, which induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Learn More

    Starting at: $55.00

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  • SJ 172550

    SJ 172550 is a MDMX inhibitor, which reversibly binds MDMX (EC50 = 2.3 μM), and inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis. Learn More

    Starting at: $119.00

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  • NSC 146109 hydrochloride

    NSC 146109 hydrochloride is cell-permeable, genotype-selective antitumor agent that increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Learn More

    Starting at: $109.00

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  • MIRA-1

    MIRA-1 is a Restores wild-type conformation, function and DNA binding activity to mutant p53 that induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM). Learn More

    Starting at: $89.00

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  • PhiKan 083

    PhiKan 083 is a p53 stabilizing agent that binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Learn More

    Starting at: $125.00

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7 Item(s)

per page