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Nuclear Receptors
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Calcipotriol
Calcipotriol is a Vitamin D3 analog that displays minimal effects on calcium homeostasis, which regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines. Learn MoreStarting at: $115.00
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22-Oxacalcitriol
22-Oxacalcitriol is non-calcemic vitamin D3 analog and VDR ligand, which inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid. Learn MoreStarting at: $125.00
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Tacalcitol
Tacalcitol promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes. Learn MoreStarting at: $169.00
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SR 8278
SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM) and blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. Learn MoreStarting at: $115.00
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DLPC
DLPC is a selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro, which induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose, and exhibits antidiabetic effects. Learn MoreStarting at: $50.00
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GSK 4112
GSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM) which enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Learn MoreStarting at: $100.00
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Z-Guggulsterone
Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Learn MoreStarting at: $139.00
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GC 1
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively), which displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Learn MoreStarting at: $115.00
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AC 45594
AC 45594 is a selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM), which inhibits SFRE-mediated transcription. Learn MoreStarting at: $70.00
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Guggulsterone
Guggulsterone is a broad spectrum steroid receptor ligand that binds with high affinity to mineralocorticoid receptors and lower affinity to progesterone, androgen and glucocorticoid receptors. Learn MoreStarting at: $109.00
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SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
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LG 100754
LG 100754 is a novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity which displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Learn MoreStarting at: $140.00
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UVI 3003
UVI 3003 is a RXR antagonist that displays high RXR binding affinity. Learn MoreStarting at: $115.00
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Docosahexaenoic acid
Docosahexaenoic acid is a endogenous omega-3 fatty acid. It acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Learn MoreStarting at: $75.00
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HX 630
HX 630 is a RXR agonist, which acts as a retinoid synergist and enhances the potency of AM 80 in a HL-60 cell differentiation assay. Learn MoreStarting at: $149.00
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CD 3254
CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. Learn MoreStarting at: $135.00
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LG 101506
LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively), which displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Learn MoreStarting at: $139.00
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HX 531
HX 531 is a potent RXR antagonist (IC50 = 18 nM). Learn MoreStarting at: $149.00
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SR 11237
SR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity. Learn MoreStarting at: $135.00
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Fluorobexarotene
Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors), which displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene. Learn MoreStarting at: $160.00
