Nicotinic (α4β2) Receptors

Sazetidine A dihydrochloride

Sazetidine A dihydrochloride is a subtype-selective α4β2 nicotinic acetylcholine receptor ligand (Ki values are 0.26 and 54 nM at α4β2 and α3β4 receptors respectively). Learn More

Starting at: $135.00

View Details
TC 2559 difumarate

TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively), which displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Learn More

Starting at: $130.00

View Details
5-Iodo-A-85380 dihydrochloride

5-Iodo-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors, which activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively. Learn More

Starting at: $195.00

View Details
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative

5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative is a precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380. Suitable for radioiodination. Learn More

Starting at: $90.00

View Details
Desformylflustrabromine hydrochloride

Desformylflustrabromine hydrochloride is a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors (nAChRs) which selectively increases the ionic current through α4β2 in the presence of ACh. Learn More

Starting at: $119.00

View Details
3-pyr-Cytisine

3-pyr-Cytisine is a high affinity α4β2 partial agonist that exhibits antidepressant-like effects in mouse models of antidepressant efficacy. Learn More

Starting at: $139.00

View Details