Neurotransmitter Transporters
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DL-TBOA
DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 70, 6, and 6 μM for EAAT1, EAAT2 and EAAT3 respectively), which also inhibits EAAT4 and EAAT5 (Ki values are 4.4 and 3.2 μM respectively). Learn MoreStarting at: $140.00
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(±)-HIP-A
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Learn MoreStarting at: $139.00
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LY 2365109 hydrochloride
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor that induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Learn MoreStarting at: $149.00
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Org 24598 lithium salt
Org 24598 lithium salt is a selective inhibitor of the glial glycine transporter (GlyT1). pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively. Learn MoreStarting at: $139.00
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Org 25543 hydrochloride
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2), which displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Learn MoreStarting at: $139.00
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NFPS
NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity on GlyT2 or the transport of proline, GABA or glutamate (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Learn MoreStarting at: $139.00
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Sarcosine
Sarcosine is an endogenous inhibitor of GlyT1 that displays antipsychotic activity. Learn MoreStarting at: $55.00
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Dilazep dihydrochloride
Dilazep dihydrochloride is a coronary and cerebral vasodilator, suppresses the effects of ischemia. Learn MoreStarting at: $90.00
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Decynium 22
Decynium 22 is an inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM). Learn MoreStarting at: $49.00